Cancer Immunology



Health and Fitness at the Single-Cell Level
Douglas R. Green


Human Tumor Antigens Yesterday, Today, and Tomorrow
Olivera J. Finn

Masterful Antibodies: Checkpoint Blockade
Nils Lonberg and Alan J. Korman

Myeloid-Derived Suppressor Cells
Dmitry I. Gabrilovich


Immunological Mechanisms Underneath the Efficacy of Cancer Therapy
Lorenzo Galluzzi, Laurence Zitvogel and Guido Kroemer

Regulatory T Cells: Differentiation and Function
George Plitas and Alexander Y. Rudensky

Can Targeting Stroma Pave the Way to Enhanced Antitumor Immunity and Immunotherapy of Solid Tumors?
Ellen Puré and Albert Lo


Innate Lymphoid Cells in Cancer
Eric Vivier

Neoepitopes of Cancers: Looking Back, Looking Ahead
Pramod K. Srivastava

Reflections on the Histopathology of Tumor-Infiltrating Lymphocytes in Melanoma and the Host Immune Response
Martin C. Mihm, Jr and James J. Mulé

Fc-Receptor Interactions Regulate Both Cytotoxic and Immunomodulatory Therapeutic Antibody Effector Functions
Jeffrey V. Ravetch

NKG2D Receptor and Its Ligands in Host Defense
Lewis L. Lanier

The Regulatory Role of Invariant NKT Cells in Tumor Immunity
Vincenzo Cerundolo

αβ TCR-Mediated Recognition: Relevance to Tumor-Antigen Discovery and Cancer Immunotherapy
Ellis L. Reinherz

The Shared and Contrasting Roles of IL2 and IL15 in the Life and Death of Normal and Neoplastic Lymphocytes: Implications for Cancer Therapy
Thomas A. Waldmann

Modification of Cell Differentiation, One of the Mechanisms in the Surveillance of Malignancy
Eva Klein

Tumors: Wounds That Do Not Heal—Redux
Harold F. Dvorak


Eosinophils and Cancer
Marc E. Rothenberg

CD4 T-cell Subsets and Tumor Immunity: The Helpful and the Not-so-Helpful
Harvey Cantor

The Carcinoma-Associated Fibroblast Expressing Fibroblast Activation Protein and Escape from Immune Surveillance
Douglas T. Fearon

The Biology and Medical Implications of Interleukin-6
Tadamitsu Kishimoto

Affinity Enhancement of Antibodies: How Low-Affinity Antibodies Produced Early in Immune Responses Are Followed by High-Affinity Antibodies Later and in Memory B-Cell Responses
Herman Eisen

Pathogen-Sensing and Regulatory T Cells: Integrated Regulators of Immune Responses
William E. Paul

The Thymus in Immunity and in Malignancy
Harald von Boehmer

Immunomodulatory Roles of Lymphatic Vessels in Cancer Progression
Melody A. Swartz

NF-κB, an Active Player in Human Cancers
Inder Verma

The Path to Reactivation of Antitumor Immunity and Checkpoint Immunotherapy
Harvey Cantor

The Immunological Synapse
Michael L. Dustin

Chemokines in Cancer
Andrew D. Luster


The Colony-Stimulating Factors and Cancer
Donald Metcalf

Mast Cells: Potential Positive and Negative Roles in Tumor Biology
Stephen J. Galli

Macrophages: Gatekeepers of Tissue Integrity
Miriam Merad

Dendritic Cells: Master Regulators of the Immune Response
Ira Mellman

Innate Immune Cells in Inflammation and Cancer
Richard A. Flavell

Logic of the Immune System
Hidde L. Ploegh