Cancer Immunology



Mitochondria as Playmakers of CAR T-cell Fate and Longevity
Hosein Rostamian, Mohammad Khakpoor-Koosheh, Keyvan Fallah-Mehrjardi, Hamid R. Mirzaei and Christine E. Brown

Gut Microbiota and Antitumor Immunity: Potential Mechanisms for Clinical Effect
Erez N. Baruch, Jingjing Wang and Jennifer A. Wargo

Fueling the Revolution: Targeting Metabolism to Enhance Immunotherapy
Robert D. Leone and Jonathan D. Powell

Lighting a Fire: Can We Harness Pyroptosis to Ignite Antitumor Immunity?
Zhibin Zhang, Ying Zhang and Judy Lieberman


Personal Neoantigen Cancer Vaccines: A Road Not Fully Paved
Edward F. Fritsch, Ute E. Burkhardt, Nir Hacohen and Catherine J. Wu

Insights into Tumor-Associated Tertiary Lymphoid Structures: Novel Targets for Antitumor Immunity and Cancer Immunotherapy
Anthony B. Rodriguez and Victor H. Engelhard

Understanding and Overcoming the Inflammatory Toxicities of Immunotherapy
Michael Dougan

Immune Escape during Breast Tumor Progression
Carlos R. Gil Del Alcazar, Maša Alečković and Kornelia Polyak

Immunotherapy of Pediatric Solid Tumors: Treatments at a Crossroads, with an Emphasis on Antibodies
Dana L. Casey and Nai-Kong V. Cheung


Harnessing Natural Killer Cell Antitumor Immunity: From the Bench to Bedside
Karrune V. Woan and Jeffrey S. Miller

Metabolic Consequences of T-cell Costimulation in Anticancer Immunity
Alvaro Teijeira, Saray Garasa, Inaki Etxeberria, Maria Gato-Cañas, Ignacio Melero and Greg M. Delgoffe

Protective Innate Immune Variants in Racial/Ethnic Disparities of Breast and Prostate Cancer
Susan T. Yeyeodu, LaCreis R. Kidd and K. Sean Kimbro

Lessons Learned from Checkpoint Blockade Targeting PD-1 in Multiple Myeloma
Alexander M. Lesokhin, Susan Bal and Ashraf Z. Badros

Pulling RANK on Cancer: Blocking Aire-Mediated Central Tolerance to Enhance Immunotherapy
Maureen A. Su and Mark S. Anderson

The Highs and Lows of Immune-Checkpoint Blockade in Lymphoma
Stephen M. Ansell

Adoptive Immunotherapy with Antigen-Specific T Cells Expressing a Native TCR
Wingchi Leung and Helen E. Heslop

Antibody–Cytokine Fusions: Versatile Products for the Modulation of Anticancer Immunity
Dario Neri

Revolutionizing Cancer Immunology: The Power of Next-Generation Sequencing Technologies
Meromit Singer and Ana C. Anderson


The Balancing Act between Cancer Immunity and Autoimmunity in Response to Immunotherapy
Arabella Young, Zoe Quandt and Jeffrey A. Bluestone

Predictive Biomarkers for Checkpoint Immunotherapy: Current Status and Challenges for Clinical Application
Nancy Tray, Jeffrey S. Weber and Sylvia Adams

T Cell–Inflamed versus Non-T Cell–Inflamed Tumors: A Conceptual Framework for Cancer Immunotherapy Drug Development and Combination Therapy Selection
Jonathan A. Trujillo, Randy F. Sweis, Riyue Bao and Jason J. Luke

Treg Fragility: A Prerequisite for Effective Antitumor Immunity?
Abigail E. Overacre-Delgoffe and Dario A.A. Vignali

Hallmarks of T-cell Exit from Quiescence
Nicole M. Chapman and Hongbo Chi

Re(de)fining Innate Lymphocyte Lineages in the Face of Cancer
Chun Chou and Ming O. Li

Designing Late-Stage Randomized Clinical Trials with Cancer Immunotherapy: Can We Make It Simpler?
Tai-Tsang Chen

High-Dimensional Profiling of Tumor-Specific Immune Responses: Asking T Cells about What They "See" in Cancer
Evan W. Newell and Etienne Becht


A Blueprint to Advance Colorectal Cancer Immunotherapies
Dung T. Le, Vanessa M. Hubbard-Lucey, Michael A. Morse, Christopher R. Heery, Andrea Dwyer, Thomas H. Marsilje, Arthur N. Brodsky, Emily Chan, Dustin A. Deming, Luis A. Diaz Jr, Wolf H. Fridman, Richard M. Goldberg, Stanley R. Hamilton, Franck Housseau, Elizabeth M. Jaffee, S. Peter Kang, Smitha S. Krishnamurthi, Christopher H. Lieu, Wells Messersmith, Cynthia L. Sears, Neil H. Segal, Arvin Yang, Rebecca A. Moss, Edward Cha, Jill O'Donnell-Tormey, Nancy Roach, Anjelica Q. Davis, Keavy McAbee, Sharyn Worrall, and Al B. Benson

Novel “Elements” of Immune Suppression within the Tumor Microenvironment
Devikala Gurusamy, David Clever, Robert Eil, and Nicholas P. Restifo

Inflammasomes and Cancer
Rajendra Karki, Si Ming Man, and Thirumala-Devi Kanneganti


Tumor Microenvironment:
Filling the Tank: Keeping Antitumor T Cells Metabolically Fit for the Long Haul

Greg M. Delgoffe

Complementary Therapeutic Modalities:
Old-School Chemotherapy in Immunotherapeutic Combination in Cancer, A Low-cost Drug Repurposed

Rasha Abu Eid, Ghazaleh Shoja E. Razavi, Mikayel Mkrtichyan, John Janik, and Samir N. Khleif

Experimental Immunotherapies:
De-Risking Immunotherapy: Report of a Consensus Workshop of the Cancer Immunotherapy Consortium of the Cancer Research Institute

Ira Mellman, Vanessa M. Hubbard-Lucey, Matthew J. Tontonoz, Michael D. Kalos, Daniel S. Chen, James P. Allison, Charles G. Drake, Hy Levitsky, Nils Lonberg, Sjoerd H. van der Burg, Douglas T. Fearon, E. John Wherry, Israel Lowy, Robert H. Vonderheide, and Patrick Hwu

Tumor Microenvironment:
The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis

Wei Liang and Napoleone Ferrara


Statistical Challenges in the Design of Late-Stage Cancer Immunotherapy Studies
Rosemarie Mick and Tai-Tsang Chen

Experimental Immunotherapies:
Reducing Toxicity of Immune Therapy Using Aptamer-Targeted Drug Delivery

Eli Gilboa, Alexey Berezhnoy, and Brett Schrand

Experimental Immunotherapies:
T-cell–based Immunotherapy: Adoptive Cell Transfer and Checkpoint Inhibition

Roch Houot

Experimental Immunotherapies:
Tumoral Immune Resistance Mediated by Enzymes That Degrade Tryptophan

Nicolas van Baren

Engineering New Approaches to Cancer Vaccines

Naveen K. Mehta

Functional Proteomics:
Charting Immune Signaling Proteomes En Route to New Therapeutic Strategies

Eric B. Haura

Complementary Therapeutic Modalities:
Targeting Heat-Shock Protein 90 (HSP90) as a Complementary Strategy to Immune Checkpoint Blockade for Cancer Therapy

David A. Proia

Complementary Therapeutic Modalities:
The Interplay of Immunotherapy and Chemotherapy: Harnessing Potential Synergies

Leisha A. Emens

Experimental Immunotherapies:
The Emerging Understanding of Myeloid Cells as Partners and Targets in Tumor Rejection

Miranda L. Broz

Microbiota Modulation of Myeloid Cells in Cancer Therapy

Giorgio Trinchieri

Head and Neck Cancer:
Immunity in Head and Neck Cancers

Jonathan D. Schoenfeld


Experimental Immunotherapies:
PD-1 Blockade in Renal Cell Carcinoma: To Equilibrium and Beyond

Lauren C. Harshman

Prostate Cancer Immunotherapy:
Beyond Immunity to Curability for Diagnosis and Treatment

Jonathan W. Simons

HPV Infection–Associated Cancers: Next-Generation Technology for Diagnosis and Treatment

Cornelia L. Trimble

Complementary Therapeutic Modalites:
Combining Radiation and Immunotherapy: A New Systemic Therapy for Solid Tumors?
James Welsh

Experimental Immunotherapies:
Vaccines For Cancer Prevention: A Practical And Feasible Approach To The Cancer Epidemic

Olivera Finn

Experimental Immunotherapies:
Hostile, Hypoxia–A2-Adenosinergic Tumor Biology as the Next Barrier to Overcome for Tumor Immunologists

Michail V. Sitkovsky

Experimental Immunotherapies:
VISTA is a novel broad-spectrum negative checkpoint regulator for cancer immunotherapy
Randolph Noelle

Experimental Immunotherapies:
Tim-3: An Emerging Target in the Cancer Immunotherapy Landscape

Ana C. Anderson

Experimental Immunotherapies:
Oncolytic Viruses and Their Application to Cancer Immunotherapy

E. Antonio Chiocca and Samuel D. Rabkin

Experimental Immunotherapies:
IL-10: Master Switch from Tumor-Promoting Inflammation to Antitumor Immunity

Martin Oft

Experimental Immunotherapies:
Killer Immunoglobulin-like Receptors and Tumor Immunity

Don M. Benson Jr. and Michael A. Caligiuri

Pathogen-Driven Cancers and Emerging Immune Therapeutic Strategies

Paul Nghiem


Public/Private Partnership:
The Melanoma Research Alliance: The Power of Patient Advocacy to Accelerate Research and Novel Therapies

Laura Brockway-Lunardi

Complementary Therapeutic Modalities:
Harnessing the Potential of Radiation-Induced Immune Modulation for Cancer Therapy

Mansoor M. Ahmed

Complementary Therapeutic Modalities:
Temperature Matters! And Why It Should Matter to Tumor Immunologists

Elizabeth A. Repasky

Microbes and Inflammation in Colorectal Cancer

Wendy S. Garrett

Thoracic Oncology:
Immune Checkpoint Inhibitors: Making Immunotherapy a Reality for the Treatment of Lung Cancer

Drew M. Pardoll

Functional Genomics:
Getting Personal with Neoantigen-Based Therapeutic Cancer Vaccines

Catherine J. Wu