Table 2.

Comparison of proportions of newly generated BCR clones present only at later time points (T2) versus the earlier time point (T1) between treated and naïve patients.

Proportion of newly generated BCR clones
Median (min–max)
[N]
T1T2TreatedNaïveP
Week 0Week 20.74 (0.52–0.78)0.42 (0.06–0.86)0.021
[n = 6][n = 16]
Week 0Week 40.71 (0.54–0.83)0.31 (0.03–0.74)0.002
[n = 6][n = 14]
Week 0Week 60.57 (0.37–0.64)0.36 (0.04–0.76)0.109
[n = 5][n = 16]
Week 0Week 260.55 (0.50–0.69)0.56 (0.10–0.73)0.871
[n = 4][n = 13]
Week 0Week 520.65 (0.63–0.71)0.49 (0.04–0.82)0.24
[n = 4][n = 10]
Week 2Week 40.48 (0.25–0.63)0.39 (0.21–0.87)0.689
[n = 7][n = 14]
Week 2Week 60.35 (0.14–0.36)0.51 (0.02–0.89)0.098
[n = 5][n = 15]
Week 2Week 260.40 (0.22–0.87)0.64 (0.27–0.85)0.383
[n = 5][n = 12]
Week 2Week 520.45 (0.32–0.53)0.62 (0.13–0.91)0.298
[n = 5][n = 9]
Week 4Week 60.24 (0.140.41)0.64 (0.150.92)0.007
[n = 5][n = 14]
Week 4Week 260.38 (0.22–0.91)0.74 (0.32–0.86)0.246
[n = 5][n = 13]
Week 4Week 520.33 (0.24–0.63)0.58 (0.17–0.91)0.129
[n = 5][n = 10]
Week 6Week 260.51 (0.41–0.62)0.53 (0.04–0.78)0.956
[n = 4][n = 13]
Week 6Week 520.55 (0.51–0.62)0.49 (0.08–0.88)0.839
[n = 4][n = 10]
Week 26Week 520.54 (0.14–0.58)0.60 (0.07–0.72)0.414
[n = 4][n = 9]
  • Note: The proportion of newly generated BCR clones was calculated by the number of the newly generated clones divided by the total number of clones presented at either time point. Bold text highlights significant differences between treated and naïve patients (Wilcoxon rank sum test P < 0.05).