Table 1.

Binding kinetics and cross-reactivity to PD-1 and PD-L1 by Biacore.

AntibodyAnalytekon (1/Ms)koff (1/s)KD (M)
LY3434172PD-1 human4.77E+052.10E-044.41E-10
PD-1 cyno4.64E+051.30E-042.80E-10
PD-1 ratN.B.N.B.N.B.
PD-1 mouseN.B.N.B.N.B.
PD-L1 human2.69E+061.50E-035.60E-10
PD-L1 cyno2.81E+061.65E-035.88E-10
PD-L1 ratN.B.N.B.N.B.
PD-L1 mouseN.B.N.B.N.B.
LY3342903 anti–PD-1PD-1 human5.35E+052.00E-043.74E-10
PD-1 cyno4.96E+051.28E-042.58E-10
LY3300054 anti–PD-L1PD-L1 human2.44E+063.20E-041.31E-10
PD-L1 cyno2.83E+062.36E-048.33E-11
  • Abbreviations: cyno, cynomolgus monkey; M, mol/L; N.B., no detectable binding.