Table 1.

Toxicity probably or definitely related to radiation or immunotherapya

Grade 1–2Grade 3
CharacteristicsAll patients (n = 106)All patients (n = 106)Group 1: Liver 50/4b Concurrent (n = 20)Group 2: Liver 50/4 Sequential (n = 22)Group 3: Lung 50/4 Concurrent (n = 21)Group 4: Lung 50/4 Sequential (n = 24)Group 5: Liver, lung, or adrenal 60/10 Sequential (n = 19)
ALT/AST elevation5 (4.7%)5 (4.7%)1 (0.9%)001 (0.9%)3 (2.8%)
Bilirubin elevation2 (1.8%)02 (1.8%)000
Colitis1 (0.9%)2 (1.8%)01 (0.9%)001 (0.9%)
Cholecystitis1 (0.9%)0001 (0.9%)0
Diarrhea17 (16%)6 (5.6%)01 (0.9%)005 (4.7%)
Constipation2 (1.8%)1 (0.9%)00001 (0.9%)
Fatigue34 (32%)1 (0.9%)01 (0.9%)000
Fever6 (5.6%)1 (0.9%)00001 (0.9%)
Pain13 (12%)2 (1.8%)01 (0.9%)1 (0.9%)00
Pancreatitis/lipase elevation1 (0.9%)1 (0.9%)0000
Pituitary hypophysitis3 (2.8%)01 (0.9%)01 (0.9%)1 (0.9%)
TSH elevation3 (2.8%)1 (0.9%)0001 (0.9%)0
Pneumonitis2 (1.8%)1 (0.9%)0001 (0.9%)0
Chest pain1 (0.9%)001 (0.9%)00
Dyspnea12 (11%)2 (1.8%)001 (0.9%)1 (0.9%)0
Rash, maculopapular32 (30%)5 (4.7%)03 (2.8%)2 (1.8%)00
Upper muscle weakness4 (3.7%)1 (0.9%)001 (0.9%)00
Sensory neuropathy9 (8.5%)
  • Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; TSH, thyroid-stimulating hormone.

  • aNo patient experienced grade 4 or 5 toxicity probably or definitely related to treatment.

  • bIndicates the radiation dose (in Gy)/number of fractions.