Table 1.

Tumor-associated antigens

Tumor antigenExamplesTargeting strategies
ViralEBVDonor virus–specific T cells (VST) post HSCT (7, 8)
Merkel cell polyoma virusAutologous EBVSTs (10, 11, 34)
HPVThird party EBVSTs (8, 9, 38)
Autologous VSTs (39)
TILs (13)
Shared mutated antigens and fusion proteinsBCR-ABLAutologous and normal donor–specific T cells (16)
Lineage-restricted antigensMARTAutologous MART-1–specific T cells (35)
WT1Donor-derived WT1-specific T cells (26)
PR1Vaccine (40)
Cancer testis antigensNY-ESOAutologous TAA-specific T cells (22, 41)
PRAME
SSX
MAGE
Antigens overexpressed in tumorshTERTT cells with vaccine (42)
SurvivinAutologous TAA-specific T cells (41, 42)
Individual neoantigensMutation in ERBB2-interacting proteinTILs enriched for mutation-specific T cells (19)
Minor histocompatibility antigensHA1Donor-derived minor specific T cells (43)