Table 2.

Distribution of colorectal cancer samples according to F. nucleatum status in tumor tissue and lymphocytic reaction status, stratified by MSI status

F. nucleatum in colorectal cancer tissue
All casesaNegativeaPositiveaPb
Non–MSI-highTILs (n = 862)0.013
 Negative/low699 (81%)644 (82%)55 (71%)
 Intermediate119 (14%)107 (14%)12 (16%)
 High44 (5.1%)34 (4.3%)10 (13%)
Intratumoral periglandular reaction (n = 863)0.57
 Negative/low124 (14%)106 (13%)18 (23%)
 Intermediate660 (76%)613 (78%)47 (61%)
 High79 (9.2%)67 (8.5%)12 (16%)
Peritumoral lymphocytic reaction (n = 859)0.89
 Negative/low138 (16%)123 (16%)15 (20%)
 Intermediate615 (72%)567 (72%)48 (63%)
 High106 (12%)93 (12%)13 (17%)
Crohn-like lymphoid reaction (n = 723)0.001
 Negative/low586 (81%)544 (83%)42 (66%)
 Intermediate111 (15%)92 (14%)19 (30%)
 High26 (3.6%)23 (3.5%)3 (4.7%)
MSI-highTILs (n = 177)0.055
 Negative/low46 (26%)25 (21%)21 (36%)
 Intermediate64 (36%)45 (38%)19 (33%)
 High67 (38%)49 (41%)18 (31%)
Intratumoral periglandular reaction (n = 177)0.002
 Negative/low12 (6.8%)1 (0.8%)11 (19%)
 Intermediate100 (56%)68 (57%)32 (55%)
 High65 (37%)50 (42%)15 (26%)
Peritumoral lymphocytic reaction (n = 177)0.062
 Negative/low13 (7.3%)4 (3.4%)9 (16%)
 Intermediate91 (51%)62 (52%)29 (50%)
 High73 (41%)53 (45%)20 (34%)
Crohn-like lymphoid reaction (n = 151)0.13
 Negative/low64 (42%)41 (41%)23 (44%)
 Intermediate48 (32%)26 (26%)22 (42%)
 High39 (26%)32 (32%)7 (13%)
  • aPercentage indicates the proportion of cases with a specific level of lymphocytic reaction in strata of MSI status or in strata of F. nucleatum and MSI status. Total percentages may not equal 100% due to rounding.

  • bP value was calculated using the Spearman correlation test between F. nucleatum status (positive vs. negative) and each lymphocytic reaction variable [ordinal; negative/low (0), intermediate (1), and high (2)].