Table 3.

Immune-related toxicities and their treatments

IDToxicitiesSteroids treatmentDuration of steroids treatmentOngoing toxicities
1Grade 4 amylase and lipase elevationNoN/ANo
2Grade 3 pneumonitisYes2.0No
3Grade 2 pericarditisNoaN/ANo
4Grade 4 myositis, grade 3 myocarditisYesb2.0No
5Grade 3 hepatitisYes4.8No
6Grade 2 arthropathy, grade 2 rashYes12.7cYes
7Grade 2 pneumonitisYes2.3Yes
8Grade 2 blepharitisYes1.7No
9Grade 3 hypothyroidismYes1.6Yes
10Grade 3 polyarthralgias and grade 3 diabetesYes0.5Yes
11Grade 4 lipase/amylase elevation; grade 2 arthralgia; grade 3 diarrheaYesb15.0+Yes
12Grade 1 iritis, grade 2 arthralgias, grade 1 diarrheaYes1.2No
13Grade 3 hypophysitisYes17.4cYes
14Grade 1 sinusitis, grade 2 pruritusNodN/ANo
15Grade 3 acute interstitial nephritisYes1.4No
16Grade 3 joint painYesb14.8cYes
17Grade 2 myositisYes29.1cYes
18Grade 2 uveitis, grade 3 Jaccoud's arthropathyYes48.1cYes
19Grade 1 pneumonitis/diffuse pulmonary infiltratesYes2.4No
Total, n16N/A9
  • N/A, not applicable.

  • aTreated with colchicine.

  • bPatients were additionally treated with immunomodulators: intravenous immunoglobulin and infliximab (ID4). Choloroquine and methotrexate (ID11), and methotrexate (ID 16).

  • cSteroid use is ongoing.

  • dTreated with diphenhydramine.