Table 3.

Genes upregulated in tumors after treatment relative to pretreatment

GeneFold changeP
After limb infusion
 TREM112.490.023
 CCL3L110.590.009
 CCL310.360.013
 TNFRSF10C9.270.004
 CXCL38.90.042
 TREM28.090.003
 CXCR27.720.030
 CCL187.590.046
 MARCO7.430.002
 CCL237.310.016
 CXCL27.170.029
 S100A127.050.047
 SLC11A17.040.027
 CXCL16.960.039
 S100A86.90.038
 LILRA55.70.025
 C95.280.006
 CCL45.030.027
 PLAUR5.030.041
 IRGM4.840.006
 CCRL24.840.017
 IL21R4.820.016
 IL3RA4.790.001
 CD704.770.010
 ITGAX4.760.032
After limb infusion and ipilimumab
 CHIT117.270.001
 CCL188.090.001
 GZMA7.350.001
 CXCR67.230.000
 LY96.80.002
 KLRC26.680.000
 GZMH6.390.001
 GZMK6.340.003
 CCL266.250.004
 CCL36.10.010
 TREM26.010.003
 CCL3L15.950.009
 PDCD15.730.011
 SH2D1A5.40.005
 KLRK15.390.001
 CD3G5.270.006
 CD25.260.009
 NCR14.970.001
 IFNG4.90.011
 KLRG14.890.005
 IL18RAP4.880.006
 CXCR34.880.019
 CCL54.870.003
 CD274.820.015
 ICOS4.810.010
  • NOTE: Shown are the 25 genes with the greatest significant fold change.