Table 1.

Patient characteristics and levels of cell-surface OX40

UPN	OX40	FAB	Age	Sex	PBB (%) Diff.	Karyo	WBC (G/L)	Hb (g/dL)	Plt (G/L)	ELN	NCCN	MRC	Etiology
1	1.4	M0	78	m	84	45,XY, −7,+13,-21 [28], 46,XY [2]	85	6.3	20	Adverse	Poor	Poor	pAML
2	1	M0	46	m	97	46, XY	60.5	7	39	Favorable	Favorable	Better	pAML
3	3.5	M0	49	m	83	46, XY, t(1;20)(p32;p13),del(12)(p12p13)[20]	29.2	12.9	39	Intermediate II	Intermediate	Intermediate	sAML
4	2.4	M1	50	f	93	46, XX	270	8	18	Intermediate I	Intermediate	Poor	pAML
5	5.1	M1	40	m	100	complex	81.3	10.8	51	Adverse	Poor	Poor	pAML
6	1.4	M1	27	m	95	46, XY	135.1	8.1	20	Favorable	Favorable	Better	pAML
7	1.3	M1	58	m	93	46,XY	23.9	8.2	42	Intermediate I	Intermediate	Intermediate	n.a.
8	1	M1	83	f	88	n.d.	128.9	7.5	15	n.a.	n.a.	n.a.	pAML
9	2.6	M1	67	m	78	complex	11.1	8.9	48	Adverse	Poor	Poor	pAML
10	2.3	M1	76	f	76	n.d.	15.6	10.7	46	n.a.	n.a.	n.a.	pAML
11	1.3	M1	76	m	64	Complex	12180	7,3	134	Adverse	Poor	Poor	tAML
12	1.1	M1	61	m	63	46,XY[25]	59.4	13	69	Intermediate I	Intermediate	Intermediate	tAML
13	1.5	M1	68	m	86	46,XY	84.1	6.7	332	Intermediate I	Poor	Poor	pAML
14	1.5	M1	75	f	84	46, XX	150	10.8	174	Favorable	Favorable	Better	pAML
15	3.8	M1	80	f	93	n.d.	34.9	11.2	28	n.a.	n.a.	n.a.	pAML
16	1.5	M1	72	f	80	46,XX [20]	25.8	7.8	50.0	Intermediate I	Intermediate	Intermediate	pAML
17	2.8	M1	64	f	94	n.d.	222	9.2	44	n.a.	n.a.	Poor	pAML
18	1.9	M1	63	f	60	46,XX, del(9)(q22) [5]/46,XX [25]	11.3	11.3	292	Favorable	Intermediate	Intermediate	pAML
19	1.4	M1	50	m	98	46,XY	19.7	10.4	55	Favorable	Favorable	Better	pAML
20	1.4	M1	67	m	99	n.d.	67.7	9.8	23	n.a.	n.a.	n.a.	n.a.
21	1.5	M1	62	m	77	46,XY	45	7.1	270	Intermediate I	Poor	Poor	pAML
22	1.1	M1	50	f	89	46,XX, del(9)(q13,q22)[4]/46,XX [16]	13.8	8.8	25	Intemediate II	Intermediate	Intermediate	pAML
23	1	M1	44	m	75	46, XY	10.7	7.9	234	Intemediate I	Poor	Poor	pAML
24	2.2	M1	82	f	81	46, XX	130	10.1	127	Intermediate I	Intermediate	Intermediate	pAML
25	2.7	M1	47	f	98	n.d.	56.3	9.4	60	n.a.	n.a.	n.a.	pAML
26	0.9	M1	76	f	81	46,XX[20],	10.7	7.4	145	Favorable	Favorable	Better	pAML
27	6.9	M1	47	f	91	47,XX, +8	27.6	10.0	26	Intermediate II	Intermediate	Intermediate	sAML
28	1.1	M1	62	m	89	n.a.	18.3	12.3	18	n.a.	n.a.	Poor	pAML
29	1.4	M1	52	m	98	46,XY	153.3	9.2	23	Intermediate I	Poor	Poor	pAML
30	3.8	M1	56	f	87	46, X, t(X;12)(p11;p13)[14];46, XX [7]	4.14	8.3	111	Intermediate II	Intermediate	Intermediate	pAML
31	0.9	M1	68	m	93	n.d.	42.5	9.8	80	n.a.	n.a.	n.a.	pAML
32	1.7	M1	21	f	95	46,XX [16], 46,XX, del(9)(q13q22) [4]	84	7.1	30	Intermediate II	Intermediate	Poor	pAML
33	4.5	M1	41	f	92	46,XX	68.7	8.1	55	Intermediate I	Poor	Poor	pAML
34	1.1	M1	34	m	75	46, XY	33.3	10.2	11	Favorable	Favorable	Better	pAML
35	1.1	M1	38	f	60	46, XX	26	9.6	153	Intermediate I	Poor	Poor	pAML
36	1.2	M2	84	m	79	n.d.	115.2	7.8	107	n.a.	n.a.	n.a.	pAML
37	2.3	M2	30	m	53	46, XY	24.5	7.4	54	Intermediate I	Poor	Poor	pAML
38	1.1	M2	54	f	71	46,XX,t(8;21)(q22;q22)[21]	9	8.9	40	Favorable	Favorable	Better	tAML
39	1.2	M2	38	m	28	46, XY	8.8	8.7	52	Intermediate I	Intermediate	Intermediate	sAML
40	1.1	M2	72	m	97	Complex	56.9	8.9	30	Adverse	Poor	Poor	sAML
41	1.4	M2	56	m	63	46, XY	8.8	9.7	311	Favorable	Favorable	Better	pAML
42	1.2	M2	81	m	96	n.d.	10	10	46	n.a.	n.a.	n.a.	sAML
43	1.2	M2	66	m	80	n.d.	27.8	10.1	49	Favorable	Better	Better	pAML
44	2.3	M2	29	m	70	46,XY	9.6	8.5	17	Intermediate I	Poor	Poor	tAML
45	1.3	M2	73	f	83	46,X,inv(X)(p22.3q13) [14]; 46,XX [6]	5	6.3	95	Intermediate II	Intermediate	Intermediate	pAML
46	1.8	M2	73	m	83	46,XY	33.8	8.1	80	Intermediate I	Poor	Poor	pAML
47	1.4	M2	68	m	96	46,XY	85.5	9.5	146	Intermediate II	Intermediate	Intermediate	pAML
48	1.6	M2	72	m	81	46, XY, del(17)(q11q21) [6]/47,XY,+8 [3] 46, XY [16]	78.9	6,4	47	Intermediate II	Intermediate		pAML
49	1.4	M2	51	f	43	46,XX,t(2;2)(q21;q23)[21]	35.3	9.3	51	Intermediate II	Intermediate	Better	pAML
50	1.2	M2	48	m	87	46,XY	36.9	7.1	66	Favorable	Favorable	Better	pAML
51	1.8	M2	63	m	78	46,XY	180	8	30	Favorable	Favorable	Better	pAML
52	1.5	M2	64	m	82	47, XY+8[16]/47,XY,+8,del(9)(q22)[1]/46,XY,del(9)(q22)[1]/46,XY[7]	338.5	8.1	19	Intermediate II	Intermediate	Intermediate	pAML
53	0.4	M2	58	f	92	46,XX	62	7.4	25	Intermediate I	Poor	Poor	sAML
54	1.1	M2	78	m	99	45, XY, −7[7], 46, XY[15]	26	9.7	36	Adverse	Poor		sAML
55	6.4	M2	68	m	84	47,XX,+11[23]	165.5	3.8	222	Intermediate II	Intermediate	Poor	pAML
56	1.6	M2	71	f	94	46, XX	105.4	10.4	83	Intermediate I	Poor	Poor	pAML
57	1.7	M2	58	m	20	Complex	39.1	9.3	23	Adverse	Poor	Poor	pAML
58	1.3	M2	23	f	69	47,XX, +21 [2]/46,XX [23]	50	9.9	135	Intermediate II	Intermediate	Intermediate	pAML
59	1.1	M2	71	f	81	47, XX +11	26.1	9.4	10	Intermediate II	Intermediate	Intermediate	sAML
60	1.3	M2	45	m	80	Complex	17.1	9.0	51	Favorable	Favorable	Better	pAML
61	2.5	M2	44	m	94	46,XY	138.5	10.3	57	Intermediate I	Poor	Poor	pAML
62	1.1	M2	45	m	94	47, XY, +8	44.4	8.7	11	Intermediate II	Intermediate	Poor	pAML
63	2.2	M2	45	m	94	Complex	44.4	8.7	11	Adverse	Poor	Poor	pAML
64	1.3	M2	68	m	93	47, XY, +11	110.9	8	27	Intermediate II	Intermediate	Intermediate	pAML
65	0.9	M2	70	f	20	47,XX,+8,del(17)(p11-12)[5]/46,XX[20]	4	13,6	182	Adverse	Poor	Poor	sAML
66	5.7	M3	46	m	51	Complex	23.1	13.3	25	n.a.	n.a.	n.a.	pAML
67	1.1	M3	67	f	94	46,XX	99	9.9	128	Intermediate II	Intermediate	Intermediate	sAML
68	14.3	M3	65	m	40	46, XY, t(15;17)(q22;q12)[20]	6.9	8.5	17	Favorable	Favorable	Better	pAML
69	5.2	M3	58	f	96	46,XX,t(15;17)(q22;q12)[20].	42.1	8.4	17	Favorable	Favorable	Better	pAML
70	3	M4	70	f	71	45, XX, -7	282.3	5.7	68	Adverse	Poor	Poor	sAML
71	1.8	M4	49	m	72	46,Y,t(X;17)(p11;p1?1),add(21)(q22)[13]	61.9	5.8	18	Adverse	Poor	Poor	pAML
72	2.9	M4	71	m	93	47, XY, + 11 (6)	79.7	9.9	40	Intermediate II	Intermediate	Intermediate	pAML
73	1.4	M4	55	m	72	46,XY	17.2	8.6	162	Favorable	Favorable	Better	pAML
74	9.7	M4	61	m	70	46, XY	85.4	8.5	12	Intermediate I	Poor	Poor	pAML
75	6.1	M4	76	f	94	46, XX, t (9;11) (q22; q23) [12]/52, XXX, +3, +6, +8 t (t;11) (q22; q23) +12, +13, +18 [13]	141	12	70	Adverse	Poor	Poor	tAML
76	7.3	M4	43	f	86	46, XX	63.5	9.2	178	Favorable	Favorable	Better	pAML
77	1.3	M4	41	f	73	Complex	112.7	8.5	30	Adverse	Poor	Poor	pAML
78	5	M4	63	m	96	46,XY	92.3	10.5	431	Intermediate I	Poor	Poor	pAML
79	2.2	M4	73	f	85	46,XX (25)	52.6	7.5	48	Intermediate I	Poor	Poor	tAML
80	1.2	M4	71	m	75	46, XY,del(20)(q11)[6];47,idem,+11[14];	161.1	8.6	61	Intermediate II	Intermediate	Intermediate	sAML
81	1.6	M4	83	f	95	46,XX add(14)(p11)[8],/46, XX[5]	155.8	11.6	144	Intermediate II	Intermediate	Intermediate	pAML
82	2.3	M4	78	f	39	51,XX,+6,+9,+9,+11,+13[20]	8.8	9.2	146	Adverse	Poor	Poor	pAML
83	2.7	M4	64	m	22	46,XY	62.4	7.5	40	Intermediate I	Poor	Poor	n.a.
84	1.5	M4	36	m	78	46, XY	207.4	6.1	55	Intermediate I	Poor	Poor	pAML
85	2	M4	68	m	82	46, XY	148.7	9.1	134	Intermediate I	Poor	Poor	pAML
86	4.4	M4	67	m	75	46,XY,?dup(9)(p13p22)c	64.4	9.1	33	Intermediate II	Intermediate	Intermediate	pAML
87	0.6	M4	72	f	81	46,XX	26.1	8.2	70	Intermediate I	Intermediate	Interemdiate	pAML
88	2	M4	54	f	46	46, XX	17.2	10.6	167	Intermediate I	Poor	Poor	pAML
89	1	M4	57	m	68	n.d.	334	9.4	293	n.a.	n.a.	n.a.	pAML
90	2.2	M4	57	f	29	46,XX	17.5	8.0	117	Intermediate I	Intermediate	Intermediate	pAML
91	3.3	M4	56	f	64	46, XX, inv(16)(p13.1q22)[11]	56.6	10.9	99	Favorable	Favorable	Better	pAML
92	0.8	M5	70	m	90	46,XY	190	7.1	65	Intermediate I	Intermediate	Intermediate	pAML
93	1.6	M5	70	m	4	46, XY	73.6	13.2	25	Favorable	Favorable	Better	pAML
94	1.6	M5	26	f	18	46, XX	51	6,2	17	Favorable	Favorable	Better	pAML
95	7.3	M5	73	m	97	47, XY,+8[2]; 46,XY[23]	78.9	6.4	47	Intermediate II	Intermediate	Poor	tAML
96	28.5	M5	69	f	80	n.d.	275	7.1	47	n.a.	n.a.	Poor	pAML
97	1.3	M5	65	m	91	n.d.	394.2	7.9	189	n.a.	n.a.	n.a.	sAML
98	1.7	M5	69	m	11	n.d.	22.1	8.7	53	n.a.	n.a.	n.a.	pAML
99	1.1	M5	24	m	90	n.d.	n.d.	n.d.	n.d.	n.a.	n.a.	n.a.	pAML
100	1.3	M5	78	m	49	Complex	11.7	8	13	Adverse	Poor	Poor	pAML
101	1.3	M5	74	m	>90	46,XY	239	5.7	122	Intermediate I	Poor	Poor	pAML
102	9.5	M5	52	f	8	46, XX	15.7	7.2	21	Favorable	Favorable	Better	pAML
103	1.2	M5	54	m	89	46, XY, del(9)(q13q22)[8]/48, XY[16]	109.4	8.2	78	Intermediate II	Intermediate	Intermediate	pAML
104	4.6	M5	72	m	40	46,XY	14.5	5.3	28	Intermediate I	Intermediate	Intermediate	sAML
105	31.6	M5	82	m	35	n.d.	61.3	11.7	110	n.a.	n.a.	n.a.	pAML
106	1.5	M5	23	m	83	48,XY,+8,+13[17]/46,XY[3]	145.1	7.6	34	Intermediate II	Intermediate	Poor	pAML
107	1.3	M5	58	f	70	46,XX	0.6	9.1	42	Intermediate I	Poor	Poor	pAML
108	0.7	M5	45	f	80	46,XX	248.1	7.3	46	Favorable	Favorable	Better	pAML
109	18.7	M5	53	m	85	46,XY	105.6	8.1	35	Intermediate I	Poor	Poor	pAML
110	7	M5	50	m	3	46, XY	27.3	11.3	85	Intermediate I	Poor	Poor	pAML
111	0.9	M5	54	m	96	46,XY	70.3	8.1	139	Favorable	Favorable	Better	pAML

Abbreviations: UPN, uniform patient number; OX40 SFI, specific fluorescence index; FAB, French–American–British classification; F, female; M, male; PBB, peripheral blood blasts among nucleated cells; WBC, white blood count; Hb, hemoglobin; Plt, platelets; ELN, European LeukemiaNet; NCCN, National Comprehensive Cancer Network; MRC, Medical Research Council; Etiology: pAML, de novo AML; tAML, therapy-related AML; sAML, secondary AML evolving from MDS/MPS; n.d., not determined; n.a., not available.