Table 1.

Patient characteristics and levels of cell-surface OX40

UPNOX40FABAgeSexPBB (%) Diff.KaryoWBC (G/L)Hb (g/dL)Plt (G/L)ELNNCCNMRCEtiology
11.4M078m8445,XY, −7,+13,-21 [28], 46,XY [2]856.320AdversePoorPoorpAML
21M046m9746, XY60.5739FavorableFavorableBetterpAML
33.5M049m8346, XY, t(1;20)(p32;p13),del(12)(p12p13)[20]29.212.939Intermediate IIIntermediateIntermediatesAML
42.4M150f9346, XX270818Intermediate IIntermediatePoorpAML
55.1M140m100complex81.310.851AdversePoorPoorpAML
61.4M127m9546, XY135.18.120FavorableFavorableBetterpAML
71.3M158m9346,XY23.98.242Intermediate IIntermediateIntermediaten.a.
81M183f88n.d.128.97.515n.a.n.a.n.a.pAML
92.6M167m78complex11.18.948AdversePoorPoorpAML
102.3M176f76n.d.15.610.746n.a.n.a.n.a.pAML
111.3M176m64Complex121807,3134AdversePoorPoortAML
121.1M161m6346,XY[25]59.41369Intermediate IIntermediateIntermediatetAML
131.5M168m8646,XY84.16.7332Intermediate IPoorPoorpAML
141.5M175f8446, XX15010.8174FavorableFavorableBetterpAML
153.8M180f93n.d.34.911.228n.a.n.a.n.a.pAML
161.5M172f8046,XX [20]25.87.850.0Intermediate IIntermediateIntermediatepAML
172.8M164f94n.d.2229.244n.a.n.a.PoorpAML
181.9M163f6046,XX, del(9)(q22) [5]/46,XX [25]11.311.3292FavorableIntermediateIntermediatepAML
191.4M150m9846,XY19.710.455FavorableFavorableBetterpAML
201.4M167m99n.d.67.79.823n.a.n.a.n.a.n.a.
211.5M162m7746,XY457.1270Intermediate IPoorPoorpAML
221.1M150f8946,XX, del(9)(q13,q22)[4]/46,XX [16]13.88.825Intemediate IIIntermediateIntermediatepAML
231M144m7546, XY10.77.9234Intemediate IPoorPoorpAML
242.2M182f8146, XX13010.1127Intermediate IIntermediateIntermediatepAML
252.7M147f98n.d.56.39.460n.a.n.a.n.a.pAML
260.9M176f8146,XX[20],10.77.4145FavorableFavorableBetterpAML
276.9M147f9147,XX, +827.610.026Intermediate IIIntermediateIntermediatesAML
281.1M162m89n.a.18.312.318n.a.n.a.PoorpAML
291.4M152m9846,XY153.39.223Intermediate IPoorPoorpAML
303.8M156f8746, X, t(X;12)(p11;p13)[14];46, XX [7]4.148.3111Intermediate IIIntermediateIntermediatepAML
310.9M168m93n.d.42.59.880n.a.n.a.n.a.pAML
321.7M121f9546,XX [16], 46,XX, del(9)(q13q22) [4]847.130Intermediate IIIntermediatePoorpAML
334.5M141f9246,XX68.78.155Intermediate IPoorPoorpAML
341.1M134m7546, XY33.310.211FavorableFavorableBetterpAML
351.1M138f6046, XX269.6153Intermediate IPoorPoorpAML
361.2M284m79n.d.115.27.8107n.a.n.a.n.a.pAML
372.3M230m5346, XY24.57.454Intermediate IPoorPoorpAML
381.1M254f7146,XX,t(8;21)(q22;q22)[21]98.940FavorableFavorableBettertAML
391.2M238m2846, XY8.88.752Intermediate IIntermediateIntermediatesAML
401.1M272m97Complex56.98.930AdversePoorPoorsAML
411.4M256m6346, XY8.89.7311FavorableFavorableBetterpAML
421.2M281m96n.d.101046n.a.n.a.n.a.sAML
431.2M266m80n.d.27.810.149FavorableBetterBetterpAML
442.3M229m7046,XY9.68.517Intermediate IPoorPoortAML
451.3M273f8346,X,inv(X)(p22.3q13) [14]; 46,XX [6]56.395Intermediate IIIntermediateIntermediatepAML
461.8M273m8346,XY33.88.180Intermediate IPoorPoorpAML
471.4M268m9646,XY85.59.5146Intermediate IIIntermediateIntermediatepAML
481.6M272m8146, XY, del(17)(q11q21) [6]/47,XY,+8 [3] 46, XY [16]78.96,447Intermediate IIIntermediatepAML
491.4M251f4346,XX,t(2;2)(q21;q23)[21]35.39.351Intermediate IIIntermediateBetterpAML
501.2M248m8746,XY36.97.166FavorableFavorableBetterpAML
511.8M263m7846,XY180830FavorableFavorableBetterpAML
521.5M264m8247, XY+8[16]/47,XY,+8,del(9)(q22)[1]/46,XY,del(9)(q22)[1]/46,XY[7]338.58.119Intermediate IIIntermediateIntermediatepAML
530.4M258f9246,XX627.425Intermediate IPoorPoorsAML
541.1M278m9945, XY, −7[7], 46, XY[15]269.736AdversePoorsAML
556.4M268m8447,XX,+11[23]165.53.8222Intermediate IIIntermediatePoorpAML
561.6M271f9446, XX105.410.483Intermediate IPoorPoorpAML
571.7M258m20Complex39.19.323AdversePoorPoorpAML
581.3M223f6947,XX, +21 [2]/46,XX [23]509.9135Intermediate IIIntermediateIntermediatepAML
591.1M271f8147, XX +1126.19.410Intermediate IIIntermediateIntermediatesAML
601.3M245m80Complex17.19.051FavorableFavorableBetterpAML
612.5M244m9446,XY138.510.357Intermediate IPoorPoorpAML
621.1M245m9447, XY, +844.48.711Intermediate IIIntermediatePoorpAML
632.2M245m94Complex44.48.711AdversePoorPoorpAML
641.3M268m9347, XY, +11110.9827Intermediate IIIntermediateIntermediatepAML
650.9M270f2047,XX,+8,del(17)(p11-12)[5]/46,XX[20]413,6182AdversePoorPoorsAML
665.7M346m51Complex23.113.325n.a.n.a.n.a.pAML
671.1M367f9446,XX999.9128Intermediate IIIntermediateIntermediatesAML
6814.3M365m4046, XY, t(15;17)(q22;q12)[20]6.98.517FavorableFavorableBetterpAML
695.2M358f9646,XX,t(15;17)(q22;q12)[20].42.18.417FavorableFavorableBetterpAML
703M470f7145, XX, -7282.35.768AdversePoorPoorsAML
711.8M449m7246,Y,t(X;17)(p11;p1?1),add(21)(q22)[13]61.95.818AdversePoorPoorpAML
722.9M471m9347, XY, + 11 (6)79.79.940Intermediate IIIntermediateIntermediatepAML
731.4M455m7246,XY17.28.6162FavorableFavorableBetterpAML
749.7M461m7046, XY85.48.512Intermediate IPoorPoorpAML
756.1M476f9446, XX, t (9;11) (q22; q23) [12]/52, XXX, +3, +6, +8 t (t;11) (q22; q23) +12, +13, +18 [13]1411270AdversePoorPoortAML
767.3M443f8646, XX63.59.2178FavorableFavorableBetterpAML
771.3M441f73Complex112.78.530AdversePoorPoorpAML
785M463m9646,XY92.310.5431Intermediate IPoorPoorpAML
792.2M473f8546,XX (25)52.67.548Intermediate IPoorPoortAML
801.2M471m7546, XY,del(20)(q11)[6];47,idem,+11[14];161.18.661Intermediate IIIntermediateIntermediatesAML
811.6M483f9546,XX add(14)(p11)[8],/46, XX[5]155.811.6144Intermediate IIIntermediateIntermediatepAML
822.3M478f3951,XX,+6,+9,+9,+11,+13[20]8.89.2146AdversePoorPoorpAML
832.7M464m2246,XY62.47.540Intermediate IPoorPoorn.a.
841.5M436m7846, XY207.46.155Intermediate IPoorPoorpAML
852M468m8246, XY148.79.1134Intermediate IPoorPoorpAML
864.4M467m7546,XY,?dup(9)(p13p22)c64.49.133Intermediate IIIntermediateIntermediatepAML
870.6M472f8146,XX26.18.270Intermediate IIntermediateInteremdiatepAML
882M454f4646, XX17.210.6167Intermediate IPoorPoorpAML
891M457m68n.d.3349.4293n.a.n.a.n.a.pAML
902.2M457f2946,XX17.58.0117Intermediate IIntermediateIntermediatepAML
913.3M456f6446, XX, inv(16)(p13.1q22)[11]56.610.999FavorableFavorableBetterpAML
920.8M570m9046,XY1907.165Intermediate IIntermediateIntermediatepAML
931.6M570m446, XY73.613.225FavorableFavorableBetterpAML
941.6M526f1846, XX516,217FavorableFavorableBetterpAML
957.3M573m9747, XY,+8[2]; 46,XY[23]78.96.447Intermediate IIIntermediatePoortAML
9628.5M569f80n.d.2757.147n.a.n.a.PoorpAML
971.3M565m91n.d.394.27.9189n.a.n.a.n.a.sAML
981.7M569m11n.d.22.18.753n.a.n.a.n.a.pAML
991.1M524m90n.d.n.d.n.d.n.d.n.a.n.a.n.a.pAML
1001.3M578m49Complex11.7813AdversePoorPoorpAML
1011.3M574m>9046,XY2395.7122Intermediate IPoorPoorpAML
1029.5M552f846, XX15.77.221FavorableFavorableBetterpAML
1031.2M554m8946, XY, del(9)(q13q22)[8]/48, XY[16]109.48.278Intermediate IIIntermediateIntermediatepAML
1044.6M572m4046,XY14.55.328Intermediate IIntermediateIntermediatesAML
10531.6M582m35n.d.61.311.7110n.a.n.a.n.a.pAML
1061.5M523m8348,XY,+8,+13[17]/46,XY[3]145.17.634Intermediate IIIntermediatePoorpAML
1071.3M558f7046,XX0.69.142Intermediate IPoorPoorpAML
1080.7M545f8046,XX248.17.346FavorableFavorableBetterpAML
10918.7M553m8546,XY105.68.135Intermediate IPoorPoorpAML
1107M550m346, XY27.311.385Intermediate IPoorPoorpAML
1110.9M554m9646,XY70.38.1139FavorableFavorableBetterpAML
  • Abbreviations: UPN, uniform patient number; OX40 SFI, specific fluorescence index; FAB, French–American–British classification; F, female; M, male; PBB, peripheral blood blasts among nucleated cells; WBC, white blood count; Hb, hemoglobin; Plt, platelets; ELN, European LeukemiaNet; NCCN, National Comprehensive Cancer Network; MRC, Medical Research Council; Etiology: pAML, de novo AML; tAML, therapy-related AML; sAML, secondary AML evolving from MDS/MPS; n.d., not determined; n.a., not available.