Table 2.

Summary of cell density measurements

Cell densityTotal (N = 29) Mean, cells/mm2; median, cells/mm2 (range)Primary (n = 12) Mean, cells/mm2; median, cells/mm2 (range)Metastatic (n =17) Mean, cells/mm2; median, cells/mm2 (range)Significance between primary and metastatic (P)
CD8 (invasive margin)107.9; 44.1 (0–730)73.0; 9.9 (0–730)132.5; 100.3 (23.1–357.1)0.0003
PD-1 (invasive margin)82.5; 48.9 (1.8–361.6)41.6; 8.9 (1.8–293.2)111.3; 83.4 (16.2–361.6)0.002
PD-L1 (invasive margin)174.2; 113.9 (0–1035)80.0; 5.7 (0–862.8)240.6; 194.5 (15.8–1,035)0.0003
CD8 (intratumor)53.4; 15.0 (1.3–414.3)26.2; 8.1 (2.2–204.7)72.6; 36.9 (1.3–414.3)0.11
PD-1 (intratumor)36.9; 11.1 (1.1–309)24.8; 5.3 (1.1–182.9)45.5; 20.9 (1.5–309)0.08
PD-L1 (intratumor)173.3; 24.3 (1.5–1,940)171.3; 5.6 (1.5–1,940)174.7; 53.7 (1.6–1,177)0.006
NY-ESO-15,024; 5,334 (566–9,170)4,682; 5,050 (566–8,693)5,265; 5,920 (946–9,170)0.44