Table 1.

Aggregated fold changes of circulating cytokines/chemokines in the Ipi-Bev–treated melanoma patients

Cytokine/chemokineNMinMedianMaxWilcoxon signed-rank P value
TNFα430.361.714.29<0.0001
IL8430.041.6719.50.0007
CXCL10430.421.5230.68<0.0001
CXCL1430.561.29194.8<0.0001
IL1α430.431.2416.14<0.0001
IFNα2430.261.2410.450.0001
CCL4430.211.1514.70.002
CCL11430.591.0937.850.03
EGF430.061.0618.830.29
FGF2430.28150.110.17
GM-CSF430.3214.150.52
CSF3430.1518.130.03
IFNγ430.09141.410.08
CCL2430.150.98142.30.73
CCL22430.330.89142.20.57
VEGFA430.030.13.02<0.0001
  • NOTE: Cytokines/chemokines were quantitatively analyzed. A Bonferroni correction was used to control the overall type-1 error. Based on 39 cytokines, statistical significance is defined as P < 0.0013. Cytokines/chemokines with significant increases are depicted in red. VEGF exhibited significant decrease and is depicted in blue. All others are presented in black.