Table 2

Treatment-related adverse events for 21 non-placebo subjects evaluable for toxicity.

Event Subjects with Any Toxicity Subjects with Grade 3 Toxicity
No. % No. %
Fever 8 38 - -
Lethargy 8 38 - -
Nausea or vomiting 8 38 1 5
Pain, including tumor pain 8 33 1 5
Headache 5 24 - -
Arthralgia/myalgia 4 19 1 5
Subcutaneous rhIL-12 injection site reactiona 4 33 - -
Anemia 3 14 - -
Rigors 2 10 - -
Gout/hyperuricemia 2 10 1 5
Lymphopenia 1 5 - -
Sweats 1 5 - -

aSubcutaneous injection subjects only (n=12).