Table 6

Cytotoxic lymphocyte response to Melan-A peptide.

Patient Day Response
Pre 8 15 22 57 85
1 0 - 3 1 1 0 Na
2 0 - 0 0 0 0 N
3 0 - 0 0 - - N
4 NE NE - - - - NE
5 0 0 0 0 0 0 N
6 0 0 0 0 0 0 N
7 4 3 1 1 0 1 N
8 5 - - 9 - - NE
9 0 - - 3 - - NE
10 1 - 3 5 - - Y
11 NE NE - - - - NE
12 NE NE - - - - NE
13 1 0 1 0 1 1 N
14 1 0 0 0 0 1 N
15 0 0 0 0 0 0 N
16 3 1 0 2 1 0 N
17 0 - 1 0 0 0 N
18 1 - 2 24 24 19 Y
19 2 - 0 1 0 1 N
20 0 0 0 0 0 0 N
21 0 0 0 0 0 0 N
22 4 3 1 1 0 1 N
23 0 - 0 0 0 0 N
24 0 - 0 5 0 NE Y
25 5 5 3 NE NE - N
26 0 0 0 0 1 NE N
27 1 1 0 0 0 NE N
28 0 0 0 0 - - N

aCytotoxicity assay was negative; however the blood was positive for Melan-A-responsive CD8+ cells by ELIspot assay (15 spots/105 cells pre-study increasing to 100 spots/105 cells on day 85).