Table 1

Binding of human monoclonal anti-NY-ESO-1 antibodies to NYESO-1. Comparison of EC50 and equilibrium affinity constants for the binding between NY-ESO-1 and different anti-NY-ESO-1 antibodies.

AntibodyEC50 [pM] (prok. NY-ESO-1)KD [M] (prok. NY-ESO-1)KD [M] (euk. NY-ESO-1)
12D71.142.08×10−101.56×10−10
1D42.231.62×10−92.24×10−10
30D61.094.35×10−92.65×10−9
31E49.521.9×10−82.23×10−8
15B1272.6------
E978 control6.662.56×10−81.56×10−11