Table 1

Tumor ascites fluid inhibits the activation of both NFAT and NF-κB in response to TCR stimulation.

CellsTumor ascites fluidCondition%CD3+T cells with nuclear NF-κB%CD3+T cells with nuclear NFAT
Tumor associated T cellsUnactivated00
PMA + lonomycin98100
Anti-CD3, anti-CD286878
+PMA + lonomycin87100
+Anti-CD3, anti-CD282034
Normal donor peripheral blood T cellsUnactivated10
PMA + lonomycin9881
Anti-CD3, anti-CD286659
+PMA + lonomycin8893
+Anti-CD3, anti-CD282134