Table 3

SEREX-defined breast cancer antigens: Antigens associated with autoimmune disease.

NY-BR-Antigen Identity (Unigene Cluster) SEREX Database ID Number1 of Equivalent Isolate(TumorSource2) Autoimmune Disease Associations3 Reactivity with Normal Sera Reactivity with Breast Cancer Sera
9 Ifn inducible autoantigen 16 (Hs.155530)   SLE 1/12 1/10
12 RNA pol. II 23kDa subunit (Hs.24301)   SLE, PSS 1/12 1/10
14 Proteasome activator subunit 3/ Ki nuclear autoantigen (Hs.152978)   SLE 1/12 1/10
28 Glutathione S-transferase theta 1 (Hs.77490)   AH 1/12 2/10
31 Ribosomal phosphoprotein P1 (Hs.177592)   SLE 5/25 2/25
39 DBI-related protein (Hs.15250) 244 (RC), 1328 (GC), 1031(BC) AD 1/16 1/12
47 Dynamin 1-like protein (Hs.180628)   Sclero 0/20 1/20
58 Aldolase A (Hs.273415) 79 (LC) RA 0/20 1/20
59 PARP (Hs.177766) 432 (CC), 698 (RC), 939 (BC) SLE, SS, RA, PSS 1/18 1/20
64 Alanyl-tRNA synthetase (Hs.75102) 471 (RC) PM 0/20 1/20
65 Nuclear matrix protein 238 (Hs.272822)   PM, AH 0/20 1/20
69 Centromere protein F (Hs.77204) 626 (PC), 1557 (EC), 809 (BC) SLE, Sclero 8/20 1/20
91 U1 snRNP (Hs.180789) 24 (GC), 349 (CC), 1267 (RC),751 (BC) SLE, SS, RA, PM, Sclero 3/20 6/20
93 Human autoantigen (Hs.75682)   SS, SLE, Sclero, RA 0/20 1/20
97 Sjogren syndrome antigen A1 (Hs.1042)   SS, SLE 0/20 1/20
101 Vinculin (Hs.75350) 1288 (BC) thrombocytopenia 0/20 1/20

1SEREX database ID number from http://www.licr.org/SEREX.html. 2Tumor tissue abbreviations: BC, breast cancer; CC, colon cancer; EC, esophageal cancer; GC, gastric cancer; LC, lung cancer; , no additional isolates; PC, prostate cancer; RC, renal cancer. 3Autoimmune disease abbreviations: AH, autoimmune hepatitis; AD, autoimmune diabetes; PM, polymyositis; PSS, Progressive Systemic Sclerosis; RA, Rheumatoid Arthritis; Sclero, scleroderma; SLE, systemic lupus erythematosus; SS, Sjogren's Syndrome.