Table 5

SEREX-defined breast cancer antigens: Antigens reactive with sera from breast cancer patients and patients with other forms of cancer1.

NY-BR-Antigen Identity/Similarities/Motifs (Unigene cluster) SEREX Database ID Number2 of Equivalent Isolate (Tumor Source3) Seroreactivity
Breast Cancer Colon Cancer Lung Cancer Ovarian Cancer Esophageal Cancer
25 KIAA0854 protein, (Hs.30209) 128 (RC) 1/25 1/19 0/15 1/15 0/15
34 SHB adaptor protein (Hs.173752)   1/25 0/19 0/15 1/15 0/15
41 SNT-1 adaptor (Hs.251394)   1/25 0/19 1/15 0/15 0/15
45 Kinesin 2 (Hs.117977) 332 (GC), 96 (SM), 797 (RC) 2/25 0/19 0/15 0/15 0/15
53 LAGE-14 (Hs.167379)   4/25 1/19 2/15 1/15 2/15
55 Nucleosome assembly protein-1 (Hs.179662) 126 (RC), 1137 (MEL) 1/25 1/19 1/15 0/15 0/15
56 gC1Q binding protein (Hs.78614)   2/25 0/19 0/15 0/15 0/15
57 HER2 neu/erbB2 (Hs.173664)   2/25 0/19 0/15 0/15 0/15
62 Novel, kinesin similarity (Hs.278323)   2/25 0/19 0/15 0/15 0/15
63 Tumor protein D52 (Hs.2384)   2/25 0/19 0/15 0/15 0/15
72 MAGE A6 (Hs.198263)   1/25 0/19 0/15 1/15 0/15
75 Novel (Hs.5111) 1184 (MEL) 2/25 0/19 0/15 0/15 1/15
79 Tata element modulatory factor 1 (Hs.74985) 246 (GC) 1/25 0/19 0/15 0/15 0/15
94 Tumor protein p53 (Hs.1846) 33 (CC) 1/25 3/19 0/15 1/15 2/15
96 Novel, S/T kinase domain (Hs.4789) 296 (MEL) 2/25 0/19 0/15 0/15 0/15
98 MAGE D (Hs.4943)   3/25 0/19 1/15 0/15 0/15

1Antigens did not react with sera from normal individuals (0/25). 2SEREX database ID number from http://www.licr.org/SEREX.html. 3Abbreviations: BC, breast cancer; CC, colon cancer; GC, gastric cancer; MEL, melanoma; RC, renal cancer; SM, seminoma. 4Assays for LAGE-1 seroreactivity were performed using a recombinant phage expressing the highly homologous NY-ESO-1 protein.