Table 2

SEREX-defined breast cancer antigens: Reactivity with sera from normal individuals.

NY-BR-Antigen Identity/Similarities (Unigene cluster) SEREX Database ID Number1 of Equivalent Isolate(Tumor Source2) Reactivity with Normal Sera Reactivity with Breast Cancer Sera
Known Gene Products
8 H2K binding factor 2 (Hs.278573) 439 (RC), 1201 (MEL), 8 (GC) 1/16 2/10
13 Zuotin related factor 1 (Hs.82254) 6 (GC) 3/12 3/10
17 NP220 (Hs.169984) 1531 (OC) 1/12 2/10
22 Protein phosphatase 1B (Hs.5687)   1/12 1/10
23 DKFZp434L0117 (Hs.63795)   1/12 1/10
27 MHC Class I HLA Cw-0304 (Hs.277477)   4/25 2/25
29 Proteosome subunit p112 (Hs.3887)   6/12 4/10
30 GPDH (Hs.169476)   4/12 3/10
32 Ribosomal protein L34 (Hs.250895)   2/25 2/25
35 VEGFB (Hs.78781)   1/12 2/10
36 COL6A2 (Hs.4217)   4/19 6/20
42 Vacuolar sorting protein 45B (Hs. 6650)   1/17 1/25
43 Defender against cell death-1 (Hs.82890)   8/25 5/25
50 Sphingosine-1-phosphate lyase 1 (Hs.186613)   7/12 5/10
60 HIP-55 (Hs. 180766)   2/25 1/25
61 TGFB1 anti-apoptotic factor-1 (Hs.75822) 1057 (BC) 1/25 2/25
66 FBI-1 (Hs.104640)   1/20 2/20
68 Heme oxygenase 2 (Hs.63908)   2/20 2/20
70 KIAA0713 protein (Hs.88756) 159 (LC) 1/20 4/20
71 KIAA1002 protein (Hs.102483)   2/20 4/20
74 U2 snRNP auxiliary factor-2 (Hs.103962) 786 (HD), 430 (RC) 5/16 1/20
78 RNA helicase-related protein (Hs.8765)   3/25 1/25
80 TCP1 ring complex pp 5 (Hs.1708)   1/20 1/20
82 KIAA0801 protein (Hs.17585)   1/20 3/20
88 Talin (Hs.278559) 608 (PC) 1/20 1/20
89 Candidate of metastasis 1 (Hs.8603)   1/20 1/20
90 NAP-22 (Hs.79516)   1/20 2/20
95 KIAA0376 protein (Hs.4791) 1777 (CC), 357 (RC), 551 (GC), 955 (BC) 11/20 11/20
100 BRACA-1 AP 2 (Hs.122764) 1785 (CC), 1158 (RC), 190 (PC), 1616 (OC), 807 (BC) 2/19 2/20
Novel Gene Products
15 Putative nuclear protein (Hs.178175)   1/12 1/10
16 Similar to Ankyrin (Hs.190251) 1792 (CC) 4/12 6/10
18 RNA splicing factor similarity (Hs.11065)   2/12 1/10
20 Similar to calmodulin (Hs.239812)   1/12 1/10
24 Similar to CDC 10 proteins (Hs.99741)   1/12 1/10
40 None (Hs.149190)   1/12 2/10
81 Phospholipase C beta similarity (Hs.75280)   1/20 1/20
86 Oxysterol binding protein similarity (Hs.233495) 319 (GC) 2/17 2/20
87 2 possible reading frames (Hs.18946)   1/25 1/25

1 SEREX database ID number from http://www.licr.org/SEREX.html. 2 Abbreviations: BC, breast cancer; CC, colon cancer; HD, Hodgkins disease; GC, gastric cancer; LC, lung cancer; MEL, melanoma; OC, ovarian cancer; PC, prostate cancer; RC, renal cancer