Table 2.

Significantly upregulated genes in Group A EPN from enriched STAT3 and IL6 pathway genesets

Gene symbolGene titleFCPq
MSigDB C3: motif genesets: transcription factor targets: V$STAT3_01 genes
CCL2Chemokine (C-C motif) ligand 221.621.39E−083.67E−06
IRF1Interferon regulatory factor 18.668.48E−081.11E−05
ICAM1Intercellular adhesion molecule 18.322.11E−072.00E−05
MAFFv-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)15.877.78E−075.19E−05
SERPING1Serpin peptidase inhibitor, clade G (C1 inhibitor), member 13.116.45E−060.000264
CISHCytokine inducible SH2-containing protein2.242.45E−050.000737
APBA1Amyloid beta (A4) precursor protein-binding, family A, member 11.930.004960.0393
Experimentally determined STAT3-upregulated genes (Yu et al., ref. 13)
IL8Interleukin 824.135.22E−092.17E−06
CCL2Chemokine (C-C motif) ligand 221.621.39E−083.67E−06
SOCS3Suppressor of cytokine signaling 314.611.88E−084.35E−06
TIMP1TIMP metallopeptidase inhibitor 15.493.65E−086.76E−06
ICAM1Intercellular adhesion molecule 18.322.11E−072E−05
CHI3L1Chitinase 3-like 1 (cartilage glycoprotein-39); YKL-4040.272.87E−072.51E−05
VEGFAVascular endothelial growth factor A4.719.77E−076.07E−05
PTGS2Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); COX-210.572.82E−060.000142
STAT3Signal transducer and activator of transcription 3 (acute-phase response factor)1.633.72E−060.000176
MCL1Myeloid cell leukemia sequence 1 (BCL2-related)1.657.74E−060.00031
VIMVimentin1.418.05E−060.000318
IL6Interleukin 6 (interferon, beta 2)13.411.02E−050.000381
BIRC3Baculoviral IAP repeat-containing 35.946.29E−050.001533
MMP9Matrix metallopeptidase 9 (gelatinase B, 92-kDa gelatinase, 92-kDa type IV collagenase)7.966.32E−050.00154
JAK3Janus kinase 33.566.54E−050.00157
CXCL10Chemokine (C-X-C motif) ligand 107.400.0001430.00281
LIFLeukemia inhibitory factor (cholinergic differentiation factor)3.880.0001530.00298
MMP2Matrix metallopeptidase 2 (gelatinase A, 72-kDa gelatinase, 72-kDa type IV collagenase)2.590.001110.0134
CCL5Chemokine (C-C motif) ligand 52.280.004050.0340
MYCv-myc myelocytomatosis viral oncogene homolog (avian)2.090.004140.0345
IL1BInterleukin 1, beta3.100.00640.0474
MSigDB C2: curated genesets: BioCarta: IL6_PATHWAY genes
MAP2K1Mitogen-activated protein kinase kinase 11.803.65E−060.000174
STAT3Signal transducer and activator of transcription 3 (acute-phase response factor)1.633.72E−060.000176
SHC1SHC (Src homology 2 domain containing) transforming protein 12.515.35E−060.000226
IL6Interleukin 6 (interferon, beta 2)13.411.02E−050.000381
CEBPBCCAAT/enhancer binding protein (C/EBP), beta2.014.38E−050.00114
JAK3Janus kinase 33.566.54E−050.00157
ELK1ELK1, member of ETS oncogene family1.420.0001230.00251
SRFSerum response factor (c-fos serum response element-binding transcription factor)1.770.0002340.00409
MAPK3Mitogen-activated protein kinase 31.530.0007820.0104
JUNjun proto-oncogene1.700.0009520.0120
FOSFBJ murine osteosarcoma viral oncogene homolog3.990.001400.0159