Table 1.

Enriched genesets in Group A EPN using GSEA analysisa

NameNESNOM PFDR qFWER P
MSigDB C3: motif genesets: transcription factor targets
 GGGNNTTTCC_V$NFKB_Q6_012.16<0.0001<0.0001<0.0001
 V$STAT3_012.06<0.0001<0.0001<0.0001
 V$NFKAPPAB_011.99<0.00010.0004680.001
 TGASTMAGC_V$NFE2_011.96<0.00010.0003510.001
 V$SRF_011.93<0.00010.0002810.001
 V$NFKB_Q6_011.93<0.00010.0002340.001
 V$NFKB_C1.92<0.00010.0002010.001
 V$PEA3_Q61.90<0.00010.0001760.001
 V$CREL_011.90<0.00010.0001560.001
 V$AP1_Q41.89<0.00010.0001400.001
Experimentally determined STAT3 geneset
 STAT3-upregulated (Yu et al., ref. 13)2.33<0.0001<0.0001<0.0001
MSigDB C2: curated genesets: BioCarta
 BIOCARTA_NKT_PATHWAY1.97<0.00010.006840.00400
 BIOCARTA_INFLAM_PATHWAY1.95<0.00010.003420.00400
 BIOCARTA_PML_PATHWAY1.92<0.00010.002900.00500
 BIOCARTA_LAIR_PATHWAY1.86<0.00010.01240.0270
 BIOCARTA_KERATINOCYTE_PATHWAY1.830.003380.01910.0540
 BIOCARTA_COMP_PATHWAY1.82<0.00010.01680.0570
 BIOCARTA_IL2RB_PATHWAY1.820.001660.01460.0570
 BIOCARTA_CDMAC_PATHWAY1.82<0.00010.01490.0660
 BIOCARTA_IL6_PATHWAY1.81<0.00010.01550.0770
 BIOCARTA_NFKB_PATHWAY1.800.003370.01580.0870

Abbreviations: FWER, family-wise error rate; NOM, nominal.

  • aThe top 10 enriched genesets as ranked by NES are shown for transcription factor target motif and BioCarta genesets.