Table 4.

Multivariate analysis of likelihood of pCR on Yale neoadjuvant cohort

Multivariate (TIL)Multivariate (epithelial PD-L1)Multivariate (stromal PD-L1)
VariableORa (95% CI)P valueORa (95% CI)P valueORa (95% CI)P value
Age (y)
 <50111
 ≥500.482 (0.086–2.711)0.40770.164 (0.011–2.329)0.18150.147 (0.009–2.290)0.1713
Nodal status
 Negative111
 Positive0.026 (0.003–0.219)0.00080.009 (0.0003–0.254)0.00570.009 (0.0003–0.284)0.0072
Tumor size (cm)
 <2111
 >20.110 (0.014–0.841)0.03340.054 (0.004–0.676)0.02360.072 (0.006–0.915)0.0425
Nuclear grade
 1–2111
 34.780 (0.766–29.822)0.09392.920 (0.225–37.903)0.41263.105 (0.238–40.520)0.3872
Molecular category
 HR+/HER2111
 HER2+2.908 (0.390–21.704)0.29793.624 (0.172–76.513)0.40794.156 (0.206–83.696)0.3524
 Triple-negative0.614 (0.061–6.167)0.67830.705 (0.046–10.724)0.80130.864 (0.057–13.138)0.9160
Ki-67
 Low111
 High6.186 (0.838–45.651)0.07397.945 (0.530–119.073)0.13358.550 (0.570–128.29)0.1204
LPBC
 No1
 Yes6.019 (0.035–1029.2)0.4938
Epithelial PD-L1
 Low1
 High11.120 (0.870–142.159)0.0639
Stromal PD-L1
 Low1
 High11.267 (0.779–162.95)0.0756

NOTE: Bold P values are highlighted as being less than 0.05.

Abbreviation: HR, hormone receptor.

  • aOR indicates likelihood of pCR.