Table 1.

Patient and SLN characteristics (A) and inflammatory cytokine concentrations in supernatants from 24-hour cultures of SLN cells (B)

SalineGM-CSF + PF3512676PF3512676Pb
A. Patient and SLN characteristics
Sex (male:female)4:54:56:40.755
Age (mean ± SD)47 ± 1250 ± 1258 ± 120.183
Breslow thickness (mm; mean ± SD)1.67 ± 0.552.19 ± 1.371.67 ± 0.550.493
Volume SLN (mm3; mean ± SD)a1.22 ± 0.71c2.94 ± 1.782.04 ± 1.300.031
Weight SLN (g; mean ± SD)0.95 ± 0.351.36 ± 1.191.62 ± 0.800.294
Yield scraping (×106; mean ± SD)29 ± 2577 ± 6170 ± 550.125
SLN-containing tumor cells4100.031
B. Cytokines released by SLN
IL12p7012 ± 411 ± 412 ± 30.732
TNFα30 ± 3434 ± 3138 ± 400.910
IL1044 ± 7377 ± 5583 ± 680.454
IL1β23 ± 2342 ± 3129 ± 130.243
IL6198 ± 174c1,217 ± 1,385361 ± 2930.026
IL82,872 ± 2,04710,140 ± 12,3504,167 ± 2,0300.108

NOTE: All concentrations are in pg/mL (mean ± SD).

  • aVolume: height × width × length.

  • bStatistical significance among the three patient groups by one-way ANOVA.

  • cStatistically significant difference from that of saline control group by the Tukey post hoc analysis (P < 0.05).