Table 1.

Correlation of PD-L1 expression by melanocytes with the presence of immune infiltrates is independent of BRAF mutational status

Number of cases/total cases (%)
PD-L1+aPD-L1
TotalTIL+bTILTIL+TILPc
All casesd5220/21 (95)1/21 (5)11/31 (35)20/31 (65)<0.0001
BRAF V600E2210/10 (100)0/10 (0)4/12 (33)8/12 (67)0.002
No BRAF mutation3010/11 (91)1/11 (9)7/19 (37)12/19 (63)0.007
  • a≥5% of melanocytes with membranous PD-L1 expression.

  • bIncluding mild, moderate, and severe immune infiltrates (including TILs and associated histiocytes).

  • cFisher exact test.

  • dThe relationship of melanocyte PD-L1 expression with TILs was previously reported for 21 of these cases (2).