Table 1.

Mean and SD for serum PK parameter estimates for nivolumab following single i.v. administration to monkeys

GenderDose, mg/kgCmax, μg/mLTmax, hAUC(0-T), μg × h/mLAUC(INF), μg × h/mLT(1/2), hMRT, hCLTs, mL/h/kgVss, L/kg
Male133.8 ± 2.360.25–0.54,010 ± 645a4,470 ± 423124 ± 20.3200 ± 5.20.224 ± 0.0210.046 ± 0.005
Female128.6 ± 0.6810.25–0.253,570 ± 573a4,050 ± 616139 ± 12.7210 ± 270.250 ± 0.0390.052 ± 0.002
Male10330 ± 34.20.25–0.547,100 ± 12,400b64,200 ± 27,400261 ± 226400 ± 2500.172 ± 0.0590.060 ± 0.016

NOTE: Values are mean ± SD except for Tmax, which is the range.

Abbreviations: CLT, total clearance; MRT, mean retention time; Vss, steady state volume of distribution.

  • aT = 384 hours.

  • bT = 648 hours.