Table 1.

Univariate analysis of clinicopathologic and immune characteristics for survival and recurrence

OSTTR
VariablesCutoffn(%)(months)P(months)P
Clinicopathologic
 Age, y>63795040.30.0617.50.03
≤63795050.618.5
 GenderMale905742.70.918.50.6
Female684345.617.7
 Site of primary cancerColon1016440.30.216.80.9
Rectum573650.121.2
 Perioperative chemotherapyYes1398945.60.817.70.5
No171136.959.9
 Major resection (≥3 segments)No664255.00.0216.90.09
Yes925838.527.1
 Cancer at resection marginNegative1419149.5<0.00118.80.04
Positive14919.610.1
 No. of hepatic metastasesa,bSolitary795053.00.00822.50.05
>1795037.415.7
 Size of largest tumor, cma≤51066753.70.00321.70.13
>5523333.315.0
 Preoperative CEA, ng/mLa≤2001258550.00.00119.00.002
>200221526.610.4
 Node-positive primaryaNo523367.80.00546.00.002
Yes1066741.215.9
 DFI, moa≥12885653.70.0422.50.07
<12704439.615.8
 Clinical risk score0 or 1533577.4<0.00131.4<0.001
2483150.621.4
≥3523426.610.2
Immune featuresc
 MHC-IHigh402589.00.1383.70.04
Low1187540.121.5
 β2mHigh634053.40.6425.30.44
Low946040.116.9
 CD3High362367.10.718.50.97
Low1187743.718.4
 CD4High3221110.90.0276.90.21
Low1237940.317.0
 CD8High392589.70.0946.00.38
Low1167540.117.0
Combination of immune features
 MHC-IhiCD3hiYes3120115.90.001NR0.008
No1238040.317.1
 MHC-IhiCD4hiYes3019105.70.001NR0.001
No1258139.616.9
 MHC-IhiCD8hiYes312089.70.008NR0.02
No1248040.117.0

NOTE: Log-rank test, median OS and TTR.

Abbreviation: NR, not reached.

  • aClinicopathologic features used to calculate the clinical risk score.

  • bOnly continuous variable significantly associated with OS and TTR at a level of P ≤ 0.05 (Cox regression).

  • cOptimal cutoff points by the maximally selected χ2 method, and P values corrected for overfitting.