Table 1.

Canonical pathways identified by IPA

Pathways−log (P value)Molecules
Role of pattern recognition receptors in recognition of bacteria and viruses7.42E+00OAS1, C3, OAS2, IL6, CCL5, Oas1f, OAS3, IFNA1/IFNA13, TLR2, IFIH1, IRF7, DDX58, TLR7, PIK3R6, EIF2AK2
Pathogenesis of multiple sclerosis5.33E+00CXCL10, CXCL9, CCL4, CCL5, CXCL11
Activation of IRF by cytosolic pattern recognition receptors4.38E+00DHX58, IFIH1, IRF7, DDX58, ZBP1, STAT2, IL6, IFIT2, IFNA1/IFNA13, ISG15
IFN signaling3.96E+00IFIT3, IFIT1, OAS1, MX1, IFI35, STAT2, IFNA1/IFNA13
DC maturation3.01E+00FCGR2A, HLA-DMB, IL6, MAPK13, FCGR2B, TREM2, IFNA1/IFNA13, FCGR1A, TLR2, COL1A2, IL1RN, FSCN1, PIK3R6, STAT2
Hepatic fibrosis/hepatic stellate cell activation2.58E+00COL1A2, CXCL3, FN1, CXCL9, IGF1, PDGFA, CCL21, CD14, MMP13, CCL5, IL6, IFNA1/IFNA13
Role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza2.49E+00CXCL10, CCL4, IL1RN, CCL5, IL6, IFNA1/IFNA13
Communication between innate and adaptive immune cells2.47E+00CXCL10, TLR2, CCL4, IL1RN, TLR7, CCL5, IL6, IFNA1/IFNA13, Ccl9
Role of tissue factor in cancer2.45E+00F10, PDIA2, PIK3R6, HCK, MMP13, F7, LIMK2, MAPK13, FGR, F2
LXR/RXR activation2.26E+00APOE, SCD, C3, MSR1 (includes EG:20288), IL1RN, LPL, CLU, CD14, IL6, GC