Canonical pathways identified by IPA
| Pathways | −log (P value) | Molecules |
|---|---|---|
| Role of pattern recognition receptors in recognition of bacteria and viruses | 7.42E+00 | OAS1, C3, OAS2, IL6, CCL5, Oas1f, OAS3, IFNA1/IFNA13, TLR2, IFIH1, IRF7, DDX58, TLR7, PIK3R6, EIF2AK2 |
| Pathogenesis of multiple sclerosis | 5.33E+00 | CXCL10, CXCL9, CCL4, CCL5, CXCL11 |
| Activation of IRF by cytosolic pattern recognition receptors | 4.38E+00 | DHX58, IFIH1, IRF7, DDX58, ZBP1, STAT2, IL6, IFIT2, IFNA1/IFNA13, ISG15 |
| IFN signaling | 3.96E+00 | IFIT3, IFIT1, OAS1, MX1, IFI35, STAT2, IFNA1/IFNA13 |
| DC maturation | 3.01E+00 | FCGR2A, HLA-DMB, IL6, MAPK13, FCGR2B, TREM2, IFNA1/IFNA13, FCGR1A, TLR2, COL1A2, IL1RN, FSCN1, PIK3R6, STAT2 |
| Hepatic fibrosis/hepatic stellate cell activation | 2.58E+00 | COL1A2, CXCL3, FN1, CXCL9, IGF1, PDGFA, CCL21, CD14, MMP13, CCL5, IL6, IFNA1/IFNA13 |
| Role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza | 2.49E+00 | CXCL10, CCL4, IL1RN, CCL5, IL6, IFNA1/IFNA13 |
| Communication between innate and adaptive immune cells | 2.47E+00 | CXCL10, TLR2, CCL4, IL1RN, TLR7, CCL5, IL6, IFNA1/IFNA13, Ccl9 |
| Role of tissue factor in cancer | 2.45E+00 | F10, PDIA2, PIK3R6, HCK, MMP13, F7, LIMK2, MAPK13, FGR, F2 |
| LXR/RXR activation | 2.26E+00 | APOE, SCD, C3, MSR1 (includes EG:20288), IL1RN, LPL, CLU, CD14, IL6, GC |