Table 1.

Circulating cytokine response at endpoint relative to control vaccinated rats

Cytokine response relative to control
SurvivalP < 0.05
GroupNMean ± SDIncreasedDecreased
Control538.4 ± 3.0
R-Lysate643.0 ± 2.7NSDNSD
Streptavidin651.3 ± 11.3IL-1β, IL-13, MIP-3A, VEGFM-CSF
Vaccine (50)676.8 ± 18.6
(4)Died < 77 dIL-1α, IFN-γ, MIP-3ATNF-α
(2)Survived > 100 dTNF-αIFN-γ, MIP-3A
Vaccine (100)343.5 ± 6.1NSDNSD

NOTE: The Vaccine (50) group was further divided into two groups: those surviving >100 days, considered in remission; and the remainder.

Cytokines measured that did not show statistically significant differences in any groups: IL-2, IL-4, IL-5, IL-6, IL-7, IL-10, IL-12, IL-17, IL-18, EPO, G-CSF, GRO-KC, MIP-1A, and Rantes.

Abbreviations: M-CSF, macrophage colony-stimulating factor; N, number in each cohort; NSD, no statistically significant differences.