Circulating cytokine response at endpoint relative to control vaccinated rats
| Cytokine response relative to control | ||||
|---|---|---|---|---|
| Survival | P < 0.05 | |||
| Group | N | Mean ± SD | Increased | Decreased |
| Control | 5 | 38.4 ± 3.0 | — | — |
| R-Lysate | 6 | 43.0 ± 2.7 | NSD | NSD |
| Streptavidin | 6 | 51.3 ± 11.3 | IL-1β, IL-13, MIP-3A, VEGF | M-CSF |
| Vaccine (50) | 6 | 76.8 ± 18.6 | ||
| (4) | Died < 77 d | IL-1α, IFN-γ, MIP-3A | TNF-α | |
| (2) | Survived > 100 d | TNF-α | IFN-γ, MIP-3A | |
| Vaccine (100) | 3 | 43.5 ± 6.1 | NSD | NSD |
NOTE: The Vaccine (50) group was further divided into two groups: those surviving >100 days, considered in remission; and the remainder.
Cytokines measured that did not show statistically significant differences in any groups: IL-2, IL-4, IL-5, IL-6, IL-7, IL-10, IL-12, IL-17, IL-18, EPO, G-CSF, GRO-KC, MIP-1A, and Rantes.
Abbreviations: M-CSF, macrophage colony-stimulating factor; N, number in each cohort; NSD, no statistically significant differences.