Table 4.

Multiple costimulatory molecules encoded within poxviral vectors dramatically increase avidity of tumor-specific T cells in a murine model

VaccinePrecursor frequency/105 CD8+ T cellsΔ PrecursorPeptide concentration for CTL (nmol/L)Δ Aviditya
rV-CEA3211.0X5101X
rV-CEA-TRICOM7692.4X5102X

Abbreviation: CTL, cytotoxic T lymphocytes.

  • aDefined as natural log of the peptide concentration that results in 50% maximal target lysis. Similar results were seen with tetramer dissociation. Adapted from (26).