Table 1.

Therapy timeline and laboratory values

Patient 1Patient 2
Anti-PD-1 therapyNivolumab, 3 mg/kgMK-3475, 2 mg/kg
Anti-PD-1 treatment datesNovember 5, 2012–December 17, 2012October 12, 2012–December 14, 2012
Vemurafenib (vem) start dateJanuary 8, 2013January 22, 2013
Hospitalization datesJanuary 21, 2013–January 29, 2013February 3, 2013–February 7, 2013
Laboratory values (reference)Pre-vemAdmissionPre-vemAdmission
Hemoglobin (11.8–16.0 g/dL)12.29.5 (after IV fluids)12.610.8 (after IV fluids)
Platelets (135,000–371,000/mm3)41243 (after IV fluids)24093 (after IV fluids)
Creatinine (0.7–1.5 g/dL)0.73.700.52.09
Aspartate aminotransferase (4–40 U/L)202002756
Date of subsequent admissionFebruary 4, 2013March 5, 2013