Table 1.

Ranking of differentially expressed immune genes between the mesenchymal (M) and proneural (P) subsets

GeneRoleFold change M relative to PP valueRank among all genes
Immune activators
TIMP1Regulates resistance to infection4.34.2 × 10−4512
SERPING1Complement activation2.31.1 × 10−3471
TNFRSF14TNF family member2.33.1 × 10−3481
LGALS3Galectin-3 that induces immunosuppression4.83.0 × 10−3393
TNFAIP3Terminates TNF-induced NF-κB responses2.02.6 × 10−30139
CCR2Monocyte chemoattractant protein2.57.0 × 10−28213
IL-15Enhances immunity of CD8+ T cells2.32.2 × 10−27232
LPXNSubstrate for tyrosine kinase1.74.0 × 10−27238
FAST-cell apoptosis2.78.3 × 10−26294
TNFSF4Encodes OX40 ligand2.31.8 × 1 0−25305
PTGER4Prostaglandin E receptor 42.22.2 × 10−24346
CCL2Monocyte chemotactic protein3.79.9 × 10−24386
SOX11Signal transducer molecule−2.51.3 × 10−23401
LYNInhibitory role in myeloid proliferation1.53.2 × 10−22492
THYBS1Thrombospondin 1; assists in tumor death1.98.1 × 10−22532
IRAK3Negative regulator of TLR signaling2.02.3 × 10−21568
GDF15TGF-β superfamily member2.87.1 × 10−21611
PRDM1Represses IFN-β gene expression1.67.8 × 10−21617
MICBActivates cytolytic response of NK and CD8 T cells1.55.6 × 10−20696
IL-6RKey immunosuppressive pathway1.76.4 × 10−20707
Immunosuppressors
TIMP1Regulates resistance to infection4.34.2 × 10−4512
ANXA1Enhances/inhibits adaptive immunity3.33.4 × 10−4123
TNFRSF1ATumor necrosis superfamily protein2.25.4 × 10−4031
MR1Antigen presentation function2.12.2 × 10−3745
KLRC2Encodes NKG2-C (expressed on NK cells)−10.91.3 × 10−3650
SERPING1Complement activation2.31.1 × 10−3471
LTBP1Activates TGF-β3.21.0 × 10−32100
SWAP70Mediates IgE responses/antibody switch2.12.1 × 10−32109
SATB1Silencing mimics the effects of IFN-γ treatment−2.44.5 × 10−32114
TGFBR2TGF-β2 receptor1.76.0 × 10−32120
SHC1Inhibits adaptive immune responses1.91.0 × 10−31125
LGALS1Galectin 1—deactivates M1 macrophages2.31.1 × 10−31127
RELBInteracts with NF-κβ22.04.1 × 10−31135
DLL1T-cell activation−2.04.4 × 10−30142
BCL3Regulates NF-κβ2.76.3 × 10−30146
RAB27AGranulocyte exocytosis2.21.3 × 10−29157
NOD1Innate immunity1.81.4 × 10−29160
KLRC1Recognition of MHC class I molecules by NK cells−3.01.5 × 10−28161
CHI3L1YKL-40 immunosuppressor in gliomas3.02.2 × 10−29170
ICAM1Transmigration receptor for immune cells2.74.9 × 10−29182

Abbreviation: IgE, immunoglobulin E.