Table 1.

Patient profiles

Patient ID09-079-109-079-709-079-1009-079-17
Age (years)63493954
GenderMaleMaleFemaleFemale
PS (Karnofsky)90909090
StageIVIVIVIV
Metastatic lesionsAdrenal gland, liver, peritonealLung, lymph nodes, pancreas, retroperitoneum, bone, soft tissue, thoracic nodes, spleenLung, thoracic nodes, spleen, liverSkin, axillary lymph node and mesenteric mass
WBC (×103/mm2)7.08.23.97.7
ALC (×103/mm2)1.61.11.21.8
Adverse event (grade)Fatigue (G1)Diarrhea (G1)Fatigue (G2)Pruritus (G1)
Neuropathy (G1)Rash (G1)Fatigue (G1)Rash (G1)
Tinnitus (G1)Rash (G1)
Myalgia (G1)
Prior therapyTemozolomideNoneCVTGp100 DNA, High-dose IL-2, Oncovex
IMC-1121B+DTIC
CVT
Total # of doses1231112

Abbreviations: CVT, cisplatin + vinblastine + temozolomide; DTIC, dacarbazine; G, toxicity grade; IMC-1121B, ramucirumab; PS, performance status.