Patient profiles
| Patient ID | 09-079-1 | 09-079-7 | 09-079-10 | 09-079-17 |
|---|---|---|---|---|
| Age (years) | 63 | 49 | 39 | 54 |
| Gender | Male | Male | Female | Female |
| PS (Karnofsky) | 90 | 90 | 90 | 90 |
| Stage | IV | IV | IV | IV |
| Metastatic lesions | Adrenal gland, liver, peritoneal | Lung, lymph nodes, pancreas, retroperitoneum, bone, soft tissue, thoracic nodes, spleen | Lung, thoracic nodes, spleen, liver | Skin, axillary lymph node and mesenteric mass |
| WBC (×103/mm2) | 7.0 | 8.2 | 3.9 | 7.7 |
| ALC (×103/mm2) | 1.6 | 1.1 | 1.2 | 1.8 |
| Adverse event (grade) | Fatigue (G1) | Diarrhea (G1) | Fatigue (G2) | Pruritus (G1) |
| Neuropathy (G1) | Rash (G1) | Fatigue (G1) | Rash (G1) | |
| Tinnitus (G1) | Rash (G1) | |||
| Myalgia (G1) | ||||
| Prior therapy | Temozolomide | None | CVT | Gp100 DNA, High-dose IL-2, Oncovex |
| IMC-1121B+DTIC | ||||
| CVT | ||||
| Total # of doses | 12 | 3 | 11 | 12 |
Abbreviations: CVT, cisplatin + vinblastine + temozolomide; DTIC, dacarbazine; G, toxicity grade; IMC-1121B, ramucirumab; PS, performance status.