Table 2.

Adverse events with maximum grade 3

SB-485232 doses + DOXIL 40 mg/m2
1 μg/kg3 μg/kg10 μg/kg30 μg/kg100 μg/kgTotal
N = 3N = 4N = 3N = 3N = 3N = 16
Preferred termn (%)n (%)n (%)n (%)n (%)n (%)
Any AE1 (33)3 (75)1 (33)2 (67)1 (33)8 (50)
Anemia02 (50)001 (33)3 (19)
Abdominal pain001 (33)001 (6)
Asthenia001 (33)001 (6)
Dehydration1 (33)00001 (6)
Drug hypersensitivity (to PLD)01 (25)0001 (6)
Edema peripheral0001 (33)01 (6)
Fatigue0001 (33)01 (6)
Hyperglycemia01 (25)0001 (6)
Hyperkalemia01 (25)0001 (6)
Jaundice1 (33)00001 (6)
Musculoskeletal pain0001 (33)01 (6)
Nausea001 (33)001 (6)
Pyelonephritis0001 (33)01 (6)
Vomiting001 (33)001 (6)

Abbreviation: AE, adverse event.