PT - JOURNAL ARTICLE AU - Chen, Jin TI - HIF1α or HIF2α: Enhancing CD8<sup>+</sup> T-cell Fitness for Antitumor Immunity AID - 10.1158/2326-6066.CIR-21-0114 DP - 2021 Apr 01 TA - Cancer Immunology Research PG - 364--364 VI - 9 IP - 4 4099 - http://cancerimmunolres.aacrjournals.org/content/9/4/364.short 4100 - http://cancerimmunolres.aacrjournals.org/content/9/4/364.full SO - Cancer Immunol Res2021 Apr 01; 9 AB - Adoptive T-cell therapy requires the transferred lymphocytes to adapt to the hypoxic tumor microenvironment. In this issue, Veliça and colleagues found that modified HIF2α expression in CD8+ T cells increases antitumor efficacy.See article by Veliça et al., p. 401