PT  - JOURNAL ARTICLE
AU  - Campbell, Kerry S.
TI  - Mystery Checkpoint Revealed: KIR3DL3 Finally Found a Ligand in HHLA2
AID  - 10.1158/2326-6066.CIR-20-0996
DP  - 2021 Feb 01
TA  - Cancer Immunology Research
PG  - 128--128
VI  - 9
IP  - 2
4099  - http://cancerimmunolres.aacrjournals.org/content/9/2/128.short
4100  - http://cancerimmunolres.aacrjournals.org/content/9/2/128.full
SO  - Cancer Immunol Res2021 Feb 01; 9
AB  - Inhibitory killer cell immunoglobulin–like receptors (iKIR) tolerize natural killer cells and some T cells upon detecting classical HLA class I molecules. In this issue, Bhatt and colleagues identify the B7 family member HHLA2 as an unanticipated ligand for a peculiar iKIR family member, KIR3DL3. These data establish a new inhibitory checkpoint pathway that may protect HHLA2+ tumor cells from immune attack.See article by Bhatt et al., p. 156