RT Journal Article
SR Electronic
T1 Health and Fitness at the Single-Cell Level
JF Cancer Immunology Research
JO Cancer Immunol Res
FD American Association for Cancer Research
SP 130
OP 135
DO 10.1158/2326-6066.CIR-20-0418
VO 9
IS 2
A1 Green, Douglas R.
YR 2021
UL http://cancerimmunolres.aacrjournals.org/content/9/2/130.abstract
AB Genetically identical cells in a tissue can respond differently to perturbations in their environment or “stress.” Such stresses can be physicochemical, mechanical, or infectious or may come from competition with other cells in the tissue. Here, I discuss how the varying responses to stress influence the decision of a cell to repair or die, and how one cell's response can have effects on surrounding cells. Such responses control the health and fitness of single cells and how they compete with other genetically identical cells.See related article on p. 129