PT - JOURNAL ARTICLE AU - Green, Douglas R. TI - Health and Fitness at the Single-Cell Level AID - 10.1158/2326-6066.CIR-20-0418 DP - 2021 Feb 01 TA - Cancer Immunology Research PG - 130--135 VI - 9 IP - 2 4099 - http://cancerimmunolres.aacrjournals.org/content/9/2/130.short 4100 - http://cancerimmunolres.aacrjournals.org/content/9/2/130.full SO - Cancer Immunol Res2021 Feb 01; 9 AB - Genetically identical cells in a tissue can respond differently to perturbations in their environment or “stress.” Such stresses can be physicochemical, mechanical, or infectious or may come from competition with other cells in the tissue. Here, I discuss how the varying responses to stress influence the decision of a cell to repair or die, and how one cell's response can have effects on surrounding cells. Such responses control the health and fitness of single cells and how they compete with other genetically identical cells.See related article on p. 129