PT  - JOURNAL ARTICLE
AU  - Vigneron, Nathalie
AU  - Stroobant, Vincent
AU  - Van den Eynde, Benoît J.
AU  - van der Bruggen, Pierre
TI  - Database of T cell-defined human tumor antigens: the 2013 update
DP  - 2013 Jan 01
TA  - Cancer Immunity Archive
PG  - 15
VI  - 13
IP  - 3
4099  - http://cancerimmunolres.aacrjournals.org/content/13/3/15.short
4100  - http://cancerimmunolres.aacrjournals.org/content/13/3/15.full
SO  - Cancer Immun2013 Jan 01; 13
AB  - The plethora of tumor antigens that have been–and are still being–defined required systematization to provide a comprehensive overview of those tumor antigens that are the most relevant targets for cancer immunotherapy approaches. Here, we provide a new update of a peptide database resource that we initiated many years ago. This database compiles all human antigenic peptides described in the literature that fulfill a set of strict criteria needed to ascertain their actual “tumor antigen” nature, as we aim at guiding scientists and clinicians searching for appropriate cancer vaccine candidates (www.cancerimmunity.org/peptide). In this review, we revisit those criteria in light of recent findings related to antigen processing. We also introduce the 29 new tumor antigens that were selected for this 2013 update. Two of the new peptides show unusual features, which will be briefly discussed. The database now comprises a total of 403 tumor antigenic peptides. This article was published in Cancer Immunity, a Cancer Research Institute journal that ceased publication in 2013 and is now provided online in association with Cancer Immunology Research.