RT Journal Article
SR Electronic
T1 Cellular immune responses against CT7 (MAGE-C1) and humoral responses against other cancer-testis antigens in multiple myeloma patients
JF Cancer Immunity Archive
JO Cancer Immun
FD American Association for Cancer Research
SP 4
VO 10
IS 1
A1 Lendvai, Nikoletta
A1 Gnjatic, Sacha
A1 Ritter, Erika
A1 Mangone, Michael
A1 Austin, Wayne
A1 Reyner, Karina
A1 Jayabalan, David
A1 Niesvizky, Ruben
A1 Jagannath, Sundar
A1 Bhardwaj, Nina
A1 Chen-Kiang, Selina
A1 Old, Lloyd J.
A1 Cho, Hearn Jay
YR 2010
UL http://cancerimmunolres.aacrjournals.org/content/10/1/4.abstract
AB The type I melanoma antigen gene (MAGE) proteins CT7 (MAGE-C1) and MAGE-A3 are commonly expressed in multiple myeloma (MM), and their expression correlates with increased plasma cell proliferation and poor clinical outcome. They belong to the cancer-testis antigen (CTAg) group of tumor-associated proteins, some of which elicit spontaneous immune responses in cancer patients. CT7 and MAGE-A3 are promising antigenic targets for therapeutic tumor vaccines in myeloma; therefore, it is critical to determine if they are immunogenic in MM patients. We analyzed cellular and humoral immune responses against CTAgs in patients with plasma cell dyscrasias: MM, monoclonal gammopathy of undetermined significance (MGUS), and Waldenström's macroglobulinemia (WM). Bone marrow lymphocytes from two of four untreated MM patients exhibited CT7-specific cellular immune responses as measured by an autologous cellular immunity assay, the first such immune response to CT7 to be reported in cancer patients. Sera from 24 patients were screened by ELISA for humoral immune responses to CTAgs. Two patients with MM demonstrated positive titers, one for MAGE-A1 and the other for SSX1. These data demonstrate that CTAgs, particularly CT7, are immunogenic in MM patients and merit further exploration as targets of immunological therapy in MM.This article was published in Cancer Immunity, a Cancer Research Institute journal that ceased publication in 2013 and is now provided online in association with Cancer Immunology Research.