RT Journal Article
SR Electronic
T1 Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy
JF Cancer Immunity Archive
JO Cancer Immun
FD American Association for Cancer Research
SP 1
VO 10
IS 1
A1 Yuan, Jianda
A1 Page, David B.
A1 Ku, Geoffrey Y.
A1 Li, Yanyun
A1 Mu, Zhenyu
A1 Ariyan, Charlotte
A1 Gallardo, Humilidad F.
A1 Roman, Ruth-Ann
A1 Heine, Agnes I.
A1 Terzulli, Stephanie L.
A1 Ritter, Erika
A1 Gnjatic, Sacha
A1 Ritter, Gerd
A1 Jungbluth, Achim A.
A1 Allison, James P.
A1 Old, Lloyd J.
A1 Wolchok, Jedd D.
YR 2010
UL http://cancerimmunolres.aacrjournals.org/content/10/1/1.abstract
AB Melanoma patients treated with anti-CTLA-4 have shown a range of anti-tumor responses. In this report, we describe the response of a single patient to anti-CTLA-4, with individual lesions disappearing, others stabilizing, and others progressing. These responses can be viewed as a clear manifestation of cancer immunoediting and its three phases of elimination, equilibrium and escape, with each tumor in this patient being at a discrete stage in the process. The patient's course and associated immunological monitoring and other laboratory data are presented in an immunogram, a way to visualize temporal associations between the multiple clinical and laboratory parameters.This article was published in Cancer Immunity, a Cancer Research Institute journal that ceased publication in 2013 and is now provided online in association with Cancer Immunology Research.