PT  - JOURNAL ARTICLE
AU  - Yuan, Jianda
AU  - Page, David B.
AU  - Ku, Geoffrey Y.
AU  - Li, Yanyun
AU  - Mu, Zhenyu
AU  - Ariyan, Charlotte
AU  - Gallardo, Humilidad F.
AU  - Roman, Ruth-Ann
AU  - Heine, Agnes I.
AU  - Terzulli, Stephanie L.
AU  - Ritter, Erika
AU  - Gnjatic, Sacha
AU  - Ritter, Gerd
AU  - Jungbluth, Achim A.
AU  - Allison, James P.
AU  - Old, Lloyd J.
AU  - Wolchok, Jedd D.
TI  - Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy
DP  - 2010 Jan 01
TA  - Cancer Immunity Archive
PG  - 1
VI  - 10
IP  - 1
4099  - http://cancerimmunolres.aacrjournals.org/content/10/1/1.short
4100  - http://cancerimmunolres.aacrjournals.org/content/10/1/1.full
SO  - Cancer Immun2010 Jan 01; 10
AB  - Melanoma patients treated with anti-CTLA-4 have shown a range of anti-tumor responses. In this report, we describe the response of a single patient to anti-CTLA-4, with individual lesions disappearing, others stabilizing, and others progressing. These responses can be viewed as a clear manifestation of cancer immunoediting and its three phases of elimination, equilibrium and escape, with each tumor in this patient being at a discrete stage in the process. The patient's course and associated immunological monitoring and other laboratory data are presented in an immunogram, a way to visualize temporal associations between the multiple clinical and laboratory parameters.This article was published in Cancer Immunity, a Cancer Research Institute journal that ceased publication in 2013 and is now provided online in association with Cancer Immunology Research.