RT Journal Article
SR Electronic
T1 Identification of a tumor-associated contact-dependent activity which reversibly downregulates cytolytic function of CD8+ T cells
JF Cancer Immunity Archive
JO Cancer Immun
FD American Association for Cancer Research
SP 5
VO 1
IS 1
A1 Levey, Daniel L.
A1 Udono, Heiichiro
A1 Heike, Michael
A1 Srivastava, Pramod K.
YR 2001
UL http://cancerimmunolres.aacrjournals.org/content/1/1/5.abstract
AB Tumors elicit an immune response in hosts and yet, paradoxically, often grow progressively with fatal consequences. This phenomenon has been attributed to the possible expression by tumor cells of immunomodulatory factors that overcome the anti-tumor effector functions of both specific and non-specific immune cells. This study reports on the ability of the methylcholanthrene-induced fibrosarcoma, Meth A, as well as other tumors of varied histological origins to downregulate the lytic activity of CD8+ T cells. The suppressive activity is contact-dependent and reversible. As tumor-bearing hosts are rarely immunosuppressed systemically, these findings may explain how local events within the tumor bed subvert the specific anti-tumor immune response. This article was published in Cancer Immunity, a Cancer Research Institute journal that ceased publication in 2013 and is now provided online in association with Cancer Immunology Research.