The Tumor Microenvironment Impairs Th1 IFNγ Secretion Through Alternative Splicing Modifications of Irf1 Pre-mRNA

Antoine Bernard; Christophe Hibos; Corentin Richard; Etienne Viltard; Sandy Chevrier; Sophie Lemoine; Joséphine Melin; Etienne Humblin; Romain Mary; Théo Accogli; Fanny Chalmin; Mélanie Bruchard; Paul Peixoto; Eric Hervouet; Lionel Apetoh; François Ghiringhelli; Frédérique Végran; Romain Boidot

doi:10.1158/2326-6066.CIR-19-0679

Research Article

The Tumor Microenvironment Impairs Th1 IFNγ Secretion Through Alternative Splicing Modifications of Irf1 Pre-mRNA

Antoine Bernard, Christophe Hibos, Corentin Richard, Etienne Viltard, Sandy Chevrier, Sophie Lemoine, Joséphine Melin, Etienne Humblin, Romain Mary, Théo Accogli, Fanny Chalmin, Mélanie Bruchard, Paul Peixoto, Eric Hervouet, Lionel Apetoh, François Ghiringhelli, Frédérique Végran and Romain Boidot

Antoine Bernard

1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.

2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.

3Centre Georges François Leclerc, Dijon, Burgundy, France.

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Christophe Hibos

1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.

2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.

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ORCID record for Christophe Hibos

Corentin Richard

2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.

3Centre Georges François Leclerc, Dijon, Burgundy, France.

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Etienne Viltard

1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.

2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.

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Sandy Chevrier

3Centre Georges François Leclerc, Dijon, Burgundy, France.

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Sophie Lemoine

4Genomic Platform, Institut de Biologie de l’ENS, Paris, France.

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Joséphine Melin

2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.

5LipSTIC LabEx, Dijon, Burgundy, France.

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Etienne Humblin

1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.

2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.

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Romain Mary

1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.

2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.

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Théo Accogli

1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.

2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.

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Fanny Chalmin

1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.

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Mélanie Bruchard

1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.

2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.

3Centre Georges François Leclerc, Dijon, Burgundy, France.

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Paul Peixoto

6INSERM UMR1098 “Interactions Hôte-Greffon-Tumeur & Ingénierie Cellulaire et Génique,” Besançon, France.

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Eric Hervouet

6INSERM UMR1098 “Interactions Hôte-Greffon-Tumeur & Ingénierie Cellulaire et Génique,” Besançon, France.

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ORCID record for Eric Hervouet

Lionel Apetoh

1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.

2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.

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François Ghiringhelli

1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.

2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.

3Centre Georges François Leclerc, Dijon, Burgundy, France.

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Frédérique Végran

1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.

2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.

3Centre Georges François Leclerc, Dijon, Burgundy, France.

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For correspondence: rboidot@cgfl.fr frederique.vegran@inserm.fr

Romain Boidot

1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.

2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.

3Centre Georges François Leclerc, Dijon, Burgundy, France.

7UMR CNRS 6302, Dijon, Burgundy, France.

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ORCID record for Romain Boidot
For correspondence: rboidot@cgfl.fr frederique.vegran@inserm.fr

DOI: 10.1158/2326-6066.CIR-19-0679

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This OnlineFirst version was published on February 5, 2021
doi: 10.1158/2326-6066.CIR-19-0679

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The Tumor Microenvironment Impairs Th1 IFNγ Secretion Through Alternative Splicing Modifications of Irf1 Pre-mRNA