Differential Effects of Depleting versus Programming Tumor-Associated Macrophages on Engineered T Cells in Pancreatic Ductal Adenocarcinoma

Ingunn M. Stromnes; Adam L. Burrack; Ayaka Hulbert; Patrick Bonson; Cheryl Black; J. Scott Brockenbrough; Jackson F. Raynor; Ellen J. Spartz; Robert H. Pierce; Philip D. Greenberg; Sunil R. Hingorani

doi:10.1158/2326-6066.CIR-18-0448

Research Article

Differential Effects of Depleting versus Programming Tumor-Associated Macrophages on Engineered T Cells in Pancreatic Ductal Adenocarcinoma

Ingunn M. Stromnes, Adam L. Burrack, Ayaka Hulbert, Patrick Bonson, Cheryl Black, J. Scott Brockenbrough, Jackson F. Raynor, Ellen J. Spartz, Robert H. Pierce, Philip D. Greenberg and Sunil R. Hingorani

Ingunn M. Stromnes

Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, Minnesota.

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For correspondence: ingunn@umn.edu pgreen@uw.edu srh@fhcrc.org

Adam L. Burrack

Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.

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Ayaka Hulbert

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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Patrick Bonson

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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Cheryl Black

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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J. Scott Brockenbrough

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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Jackson F. Raynor

Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.

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Ellen J. Spartz

Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota.

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Robert H. Pierce

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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ORCID record for Robert H. Pierce

Philip D. Greenberg

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, Washington.Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington.

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For correspondence: ingunn@umn.edu pgreen@uw.edu srh@fhcrc.org

Sunil R. Hingorani

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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For correspondence: ingunn@umn.edu pgreen@uw.edu srh@fhcrc.org

DOI: 10.1158/2326-6066.CIR-18-0448

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Published OnlineFirst May 3, 2019
doi: 10.1158/2326-6066.CIR-18-0448

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Differential Effects of Depleting versus Programming Tumor-Associated Macrophages on Engineered T Cells in Pancreatic Ductal Adenocarcinoma