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Cancer Immunology Research
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Correlation of high and decreased NY-ESO-1 immunity to spontaneous regression and subsequent recurrence in a lung cancer patient

Midori Isobe, Shingo Eikawa, Akiko Uenaka, Yoichi Nakamura, Tetsuo Kanda, Shigeru Kohno, Kiyotaka Kuzushima and Eiichi Nakayama
Midori Isobe
1Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Shingo Eikawa
1Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Akiko Uenaka
1Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Yoichi Nakamura
2Department of Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
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Tetsuo Kanda
3Department of Internal Medicine, Goto Central Hospital, Goto, Japan
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Shigeru Kohno
2Department of Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
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Kiyotaka Kuzushima
4Department of Immunology, Aichi Cancer Center, Nagoya, Japan
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Eiichi Nakayama
1Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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DOI:  Published January 2009
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Abstract

We show correlation between strong and decreased NY-ESO-1-specific immunity with spontaneous regression and subsequent recurrence, respectively, in a long-surviving patient with an NY-ESO-1-expressing lung adenocarcinoma. An integrated immune response consisting of IgG antibody, as well as CD4 and CD8 T cells, against NY-ESO-1 was observed at the time of spontaneous regression of multiple pleural metastases. After tumor dormancy for 3 years, the tumor started to progress. IgG antibody levels and the number of CD4 and CD8 T cells against NY-ESO-1 decreased, but were still detectable. On the other hand, the number of Foxp3+ CD25 high T regulatory cells gradually increased. The findings suggest the relevance of the NY-ESO-1 immune response and its regulation by Foxp3+ CD25 high T regulatory cells in the clinical course of this lung cancer patient.

This article was published in Cancer Immunity, a Cancer Research Institute journal that ceased publication in 2013 and is now provided online in association with Cancer Immunology Research.

Footnotes

    • Received August 4, 2009.
    • Accepted September 10, 2009.
    • Copyright © 2009 by Eiichi Nakayama
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    Cancer Immunity Archive: 9 (1)
    January 2009
    Volume 9, Issue 1
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    Correlation of high and decreased NY-ESO-1 immunity to spontaneous regression and subsequent recurrence in a lung cancer patient
    Midori Isobe, Shingo Eikawa, Akiko Uenaka, Yoichi Nakamura, Tetsuo Kanda, Shigeru Kohno, Kiyotaka Kuzushima and Eiichi Nakayama
    Cancer Immun January 1 2009 (9) (1) 8;

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    Correlation of high and decreased NY-ESO-1 immunity to spontaneous regression and subsequent recurrence in a lung cancer patient
    Midori Isobe, Shingo Eikawa, Akiko Uenaka, Yoichi Nakamura, Tetsuo Kanda, Shigeru Kohno, Kiyotaka Kuzushima and Eiichi Nakayama
    Cancer Immun January 1 2009 (9) (1) 8;
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