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Session III: Cross Presentation and Tumor Stroma

Molecular nature of the antigenic entity transferred from antigen donor cell to antigen presenting cells during cross presentation

Pramod K. Srivastava and Manish Garg
Pramod K. Srivastava
Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, CT, USA
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Manish Garg
Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, CT, USA
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DOI:  Published January 2008
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Abstract

Cross presentation involves, among other steps, transfer of antigen from the antigen expressing or antigen donor cell to the professional antigen presenting cells (1). There is considerable discussion about the nature of the antigenic entity that is transferred. It has been argued that the intact antigen itself is transferred and processed further within the antigen presenting cells (2, 3). Another line of inquiry suggests that the antigen is processed within the antigen expressing cell and the peptides generated within such cell constitute the form of antigen transferred to the antigen presenting cells (4-6). Our recent studies (7, 8) have led to observations that unify the conflicting reports in the literature and demonstrate that generation of peptides in the antigen donor cell is essential for cross presentation of ovalbumin-derived SIINFEKL epitope.

This abstract was published in Cancer Immunity, a Cancer Research Institute journal that ceased publication in 2013 and is now provided online in association with Cancer Immunology Research.

 

  • Copyright © 2008 by Pramod K. Srivastava

References

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    . Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science 1994;264:961–965.pmid:7513904
    OpenUrlAbstract/FREE Full Text
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    1. Norbury CC,
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    7. Gibbs J,
    8. Bennink JR,
    9. Yewdell JW
    . CD8+ T cell cross-priming via transfer of proteasome substrates. Science 2004;304:1318–1321.pmid:15166379
    OpenUrlAbstract/FREE Full Text
  3. 3.↵
    1. Shen L,
    2. Rock KL
    . Cellular protein is the source of cross-priming antigen in vivo. Proc Natl Acad Sci U S A 2004;101:3035–3040.pmid:14978273
    OpenUrlAbstract/FREE Full Text
  4. 4.↵
    1. Srivastava PK,
    2. Udono H,
    3. Blachere NE,
    4. Li Z
    . Heat shock proteins transfer peptides during antigen processing and CTL priming. Immunogenetics 1994;39:93–98.pmid:8276462
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  5. 5.
    1. Suto R,
    2. Srivastava PK
    . A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science 1995;269:1585–1588.pmid:7545313
    OpenUrlAbstract/FREE Full Text
  6. 6.↵
    1. Arnold D,
    2. Faath S,
    3. Rammensee H,
    4. Schild H
    . Cross-priming of minor histocompatibility antigen-specific cytotoxic T cells upon immunization with the heat shock protein gp96. J Exp Med 1995;182:885–889.pmid:7650492
    OpenUrlAbstract/FREE Full Text
  7. 7.↵
    1. Binder RJ,
    2. Srivastava PK
    . Peptides chaperoned by heat-shock proteins are a necessary and sufficient source of antigen in the cross-priming of CD8+ T cells. Nat Immunol 2005;6:593–599.pmid:15864309
    OpenUrlCrossRefPubMed
  8. 8.↵
    1. Blachère NE,
    2. Darnell RB,
    3. Albert ML
    . Apoptotic cells deliver processed antigen to dendritic cells for cross-presentation. PLoS Biol 2005;3:e185pmid:15839733
    OpenUrlCrossRefPubMed
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Cancer Immunity Archive: 8 (Suppl 2)
January 2008
Volume 8, Issue Suppl 2
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Molecular nature of the antigenic entity transferred from antigen donor cell to antigen presenting cells during cross presentation
Pramod K. Srivastava and Manish Garg
Cancer Immun January 1 2008 (8) (Suppl 2) 11;

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Molecular nature of the antigenic entity transferred from antigen donor cell to antigen presenting cells during cross presentation
Pramod K. Srivastava and Manish Garg
Cancer Immun January 1 2008 (8) (Suppl 2) 11;
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