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Cancer Immunology Research
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Session III: Cross Presentation and Tumor Stroma

Antigen presentation and the T-cell response

Michael J. Bevan
Michael J. Bevan
University of Washington School of Medicine, Seattle, WA, USA
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DOI:  Published January 2008
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Abstract

Cytotoxic T lymphocytes (CTL) recognize pathogen or tumor antigens as short peptides presented in the groove of MHC class I molecules. The peptides result from proteolysis in the cytoplasm and they load on class I molecules in the endoplasmic reticulum. This route of antigen presentation was therefore referred to as "the endogenous pathway." It was a surprise to discover that antigen from outside the presenting cells could stimulate the response of CTL, i.e. exogenous antigens could be presented by class I molecules to CTL. Evidence that first reported this will be presented as well as information on which professional antigen presenting cell is most likely to be involved in taking exogenous antigen from tumor cells for stimulation of CTL.

This abstract was published in Cancer Immunity, a Cancer Research Institute journal that ceased publication in 2013 and is now provided online in association with Cancer Immunology Research.

  • Copyright © 2008 by Michael J. Bevan
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Cancer Immunity Archive: 8 (Suppl 2)
January 2008
Volume 8, Issue Suppl 2
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Antigen presentation and the T-cell response
Michael J. Bevan
Cancer Immun January 1 2008 (8) (Suppl 2) 10;

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Antigen presentation and the T-cell response
Michael J. Bevan
Cancer Immun January 1 2008 (8) (Suppl 2) 10;
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  • Molecular nature of the antigenic entity transferred from antigen donor cell to antigen presenting cells during cross presentation
  • Open sesame: The endothelin (B) receptor mediates the tumor endothelial barrier to T-cell homing
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