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Evaluation of LAGE-1 and NY-ESO-1 expression in multiple myeloma patients to explore possible benefits of their homology for immunotherapy

Fabricio de Carvalho, Andre L. Vettore, Riguel J. Inaoka, Bruno Karia, Valéria C. C. Andrade, Sacha Gnjatic, Achim A. Jungbluth and Gisele W. B. Colleoni
Fabricio de Carvalho
1Disciplina de Hematologia e Hemoterapia, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
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Andre L. Vettore
2Departamento de Biologia, Campus Diadema, UNIFESP, Diadema, Brazil
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Riguel J. Inaoka
1Disciplina de Hematologia e Hemoterapia, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
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Bruno Karia
2Departamento de Biologia, Campus Diadema, UNIFESP, Diadema, Brazil
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Valéria C. C. Andrade
1Disciplina de Hematologia e Hemoterapia, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
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Sacha Gnjatic
3Ludwig Institute for Cancer Research, New York, NY, USA
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Achim A. Jungbluth
3Ludwig Institute for Cancer Research, New York, NY, USA
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Gisele W. B. Colleoni
1Disciplina de Hematologia e Hemoterapia, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
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DOI:  Published January 2011
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    Table 1

    International Staging System (ISS) stage and LAGE-1 and NY-ESO-1 expression in multiple myeloma patients.

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    Figure 1

    NY-ESO-1 and LAGE-1 expression as determined by immunohistochemistry. (A) Focal expression of NY-ESO-1 in the bone marrow biopsy of patient 83 using monoclonal antibody E978. (B) Expression of both LAGE-1 and NY-ESO-1 in the bone marrow biopsy of patient 115 using monoclonal antibody 219-510-23. Magnification 400x.

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    Table 2

    Peptides common to the LAGE-1 and NY-ESO-1 proteins recognized by CD4+ or CD8+ T cells.

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Cancer Immunity Archive: 11 (1)
January 2011
Volume 11, Issue 1
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Evaluation of LAGE-1 and NY-ESO-1 expression in multiple myeloma patients to explore possible benefits of their homology for immunotherapy
Fabricio de Carvalho, Andre L. Vettore, Riguel J. Inaoka, Bruno Karia, Valéria C. C. Andrade, Sacha Gnjatic, Achim A. Jungbluth and Gisele W. B. Colleoni
Cancer Immun January 1 2011 (11) (1) 1;

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Evaluation of LAGE-1 and NY-ESO-1 expression in multiple myeloma patients to explore possible benefits of their homology for immunotherapy
Fabricio de Carvalho, Andre L. Vettore, Riguel J. Inaoka, Bruno Karia, Valéria C. C. Andrade, Sacha Gnjatic, Achim A. Jungbluth and Gisele W. B. Colleoni
Cancer Immun January 1 2011 (11) (1) 1;
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