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Cancer Immunology Research
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Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy

Jianda Yuan, David B. Page, Geoffrey Y. Ku, Yanyun Li, Zhenyu Mu, Charlotte Ariyan, Humilidad F. Gallardo, Ruth-Ann Roman, Agnes I. Heine, Stephanie L. Terzulli, Erika Ritter, Sacha Gnjatic, Gerd Ritter, Achim A. Jungbluth, James P. Allison, Lloyd J. Old and Jedd D. Wolchok
Jianda Yuan
1Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan-Kettering Institute, New York, NY 10065, USA
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David B. Page
2Melanoma/Sarcoma Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
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Geoffrey Y. Ku
1Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan-Kettering Institute, New York, NY 10065, USA
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Yanyun Li
1Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan-Kettering Institute, New York, NY 10065, USA
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Zhenyu Mu
1Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan-Kettering Institute, New York, NY 10065, USA
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Charlotte Ariyan
1Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan-Kettering Institute, New York, NY 10065, USA
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Humilidad F. Gallardo
1Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan-Kettering Institute, New York, NY 10065, USA
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Ruth-Ann Roman
2Melanoma/Sarcoma Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
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Agnes I. Heine
2Melanoma/Sarcoma Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
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Stephanie L. Terzulli
1Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan-Kettering Institute, New York, NY 10065, USA
2Melanoma/Sarcoma Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
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Erika Ritter
3Ludwig Institute for Cancer Research, New York Branch, New York, NY 10065, USA
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Sacha Gnjatic
3Ludwig Institute for Cancer Research, New York Branch, New York, NY 10065, USA
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Gerd Ritter
3Ludwig Institute for Cancer Research, New York Branch, New York, NY 10065, USA
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Achim A. Jungbluth
3Ludwig Institute for Cancer Research, New York Branch, New York, NY 10065, USA
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James P. Allison
1Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan-Kettering Institute, New York, NY 10065, USA
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Lloyd J. Old
3Ludwig Institute for Cancer Research, New York Branch, New York, NY 10065, USA
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Jedd D. Wolchok
1Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan-Kettering Institute, New York, NY 10065, USA
2Melanoma/Sarcoma Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
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DOI:  Published January 2010
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This article has a correction. Please see:

  • Erratum: Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy - January 1, 2010

Abstract

Melanoma patients treated with anti-CTLA-4 have shown a range of anti-tumor responses. In this report, we describe the response of a single patient to anti-CTLA-4, with individual lesions disappearing, others stabilizing, and others progressing. These responses can be viewed as a clear manifestation of cancer immunoediting and its three phases of elimination, equilibrium and escape, with each tumor in this patient being at a discrete stage in the process. The patient's course and associated immunological monitoring and other laboratory data are presented in an immunogram, a way to visualize temporal associations between the multiple clinical and laboratory parameters.

This article was published in Cancer Immunity, a Cancer Research Institute journal that ceased publication in 2013 and is now provided online in association with Cancer Immunology Research.

  • Received October 13, 2009.
  • Accepted November 25, 2009.
  • Copyright © 2010 by Jedd D. Wolchok
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Cancer Immunity Archive: 10 (1)
January 2010
Volume 10, Issue 1
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Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy
Jianda Yuan, David B. Page, Geoffrey Y. Ku, Yanyun Li, Zhenyu Mu, Charlotte Ariyan, Humilidad F. Gallardo, Ruth-Ann Roman, Agnes I. Heine, Stephanie L. Terzulli, Erika Ritter, Sacha Gnjatic, Gerd Ritter, Achim A. Jungbluth, James P. Allison, Lloyd J. Old and Jedd D. Wolchok
Cancer Immun January 1 2010 (10) (1) 1;

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Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy
Jianda Yuan, David B. Page, Geoffrey Y. Ku, Yanyun Li, Zhenyu Mu, Charlotte Ariyan, Humilidad F. Gallardo, Ruth-Ann Roman, Agnes I. Heine, Stephanie L. Terzulli, Erika Ritter, Sacha Gnjatic, Gerd Ritter, Achim A. Jungbluth, James P. Allison, Lloyd J. Old and Jedd D. Wolchok
Cancer Immun January 1 2010 (10) (1) 1;
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