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Systematic search and molecular characterization of the antigenic targets of myeloma immunoglobulins: A monoclonal IgA from a female patient targeting sperm-specific cylicin II

Xiaoxun Xie, Rudolf Schmits, Christoph Renner, Dieter Preuß, Boris Kubuschok and Michael Pfreundschuh
Xiaoxun Xie
Medizinische Klinik I, Saarland University Medical School, Homburg, Germany
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Rudolf Schmits
Medizinische Klinik I, Saarland University Medical School, Homburg, Germany
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Christoph Renner
Medizinische Klinik I, Saarland University Medical School, Homburg, Germany
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Dieter Preuß
Medizinische Klinik I, Saarland University Medical School, Homburg, Germany
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Boris Kubuschok
Medizinische Klinik I, Saarland University Medical School, Homburg, Germany
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Michael Pfreundschuh
Medizinische Klinik I, Saarland University Medical School, Homburg, Germany
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DOI:  Published January 2001
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    Figure 1

    Localization of cylicin II in sperm cells. Calyx structures of human spermatozoa visualized by immunofluorescence microscopy using the serum of a multiple myeloma patient with a paraprotein specific for human cylicin II. The serum intensively decorates cylicin II, forming an equatorial belt around the sperm heads (red). The DNA dye DAPI was used to counterstain the nuclei.

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    Expression of cylicin II in normal human tissues and neoplasms.

    Normal tissues # positive / # tested Neoplasms # positive / # tested
    Breast 0/3 Bladder carcinoma 0/1
    Colon 0/2 Breast Cancer 0/14
    Intestine 0/1 Colorectal carcinoma 0/7
    Myocardium 0/3 Endometrial carcinoma 1/9
    Liver 0/2 Gastric cancer 0/2
    Lymph node 0/5 Glioma 0/9
    Lung 0/3 Leiomyoma 0/1
    Kidney 0/2 Lung cancer 0/11
    Ovary 0/1 Lymphoma 1/19
    Pancreas 0/1 Melanoma 0/5
    PBL 0/1 Meningioma 0/4
    PBL activated 0/1 Neuroblastoma 0/1
    Skeletal muscle 0/1 Ovarian Cancer 0/14
    Spleen 0/4 Pancreatic carcinoma 0/1
    Stomach 0/1 Prostate cancer 0/1
    Testis 2/2 Renal carcinoma 1/13
    Thyroid 0/2 T-ALL (spleen) 1/1
    Tonsil 0/5   
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Cancer Immunity Archive: 1 (1)
January 2001
Volume 1, Issue 1
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Systematic search and molecular characterization of the antigenic targets of myeloma immunoglobulins: A monoclonal IgA from a female patient targeting sperm-specific cylicin II
Xiaoxun Xie, Rudolf Schmits, Christoph Renner, Dieter Preuß, Boris Kubuschok and Michael Pfreundschuh
Cancer Immun January 1 2001 (1) (1) 11;

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Systematic search and molecular characterization of the antigenic targets of myeloma immunoglobulins: A monoclonal IgA from a female patient targeting sperm-specific cylicin II
Xiaoxun Xie, Rudolf Schmits, Christoph Renner, Dieter Preuß, Boris Kubuschok and Michael Pfreundschuh
Cancer Immun January 1 2001 (1) (1) 11;
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